Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis

Elizabeth S Gromisch,1– 4 Zaenab Dhari1,2 1Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, Hartford, CT, USA; 2Department of Rehabilitative Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT,...

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Autores principales:	Gromisch ES, Dhari Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	multiple sclerosis early cognitive impairment neuropsychological assessment modifying factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/46d70a5425f841c18f6f827a3c028345
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spelling	oai:doaj.org-article:46d70a5425f841c18f6f827a3c0283452021-12-02T13:30:39ZIdentifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis1178-2021https://doaj.org/article/46d70a5425f841c18f6f827a3c0283452021-02-01T00:00:00Zhttps://www.dovepress.com/identifying-early-neuropsychological-indicators-of-cognitive-involveme-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Elizabeth S Gromisch,1– 4 Zaenab Dhari1,2 1Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, Hartford, CT, USA; 2Department of Rehabilitative Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, USA; 3Department of Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, USA; 4Department of Neurology, University of Connecticut School of Medicine, Farmington, CT, USACorrespondence: Elizabeth S Gromisch 490 Blue Hills Avenue, Hartford, CT, 06112, USATel +860-714-2154Fax +860-714-8933Email elizabeth.gromisch@trinityhealthofne.orgAbstract: Multiple sclerosis (MS) is a debilitating disease of the central nervous system that is most commonly seen in early to middle adulthood, although it can be diagnosed during childhood or later in life. While cognitive impairment can become more prevalent and severe as the disease progresses, signs of cognitive involvement can be apparent in the early stages of the disease. In this review, we discuss the prevalence and types of cognitive impairment seen in early MS, including the specific measures used to identify them, as well as the challenges in characterizing their frequency and progression. In addition to examining the progression of early cognitive involvement over time, we explore the clinical factors associated with early cognitive involvement, including demographics, level of physical disability, disease modifying therapy use, vocational status, and psychological and physical symptoms. Given the prevalence and functional impact these impairments can have for persons with MS, considerations for clinicians are provided, such as the role of early cognitive screenings and the importance of comprehensive neuropsychological assessments.Keywords: multiple sclerosis, early cognitive impairment, neuropsychological assessment, modifying factorsGromisch ESDhari ZDove Medical Pressarticlemultiple sclerosisearly cognitive impairmentneuropsychological assessmentmodifying factorsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 323-337 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	multiple sclerosis early cognitive impairment neuropsychological assessment modifying factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	multiple sclerosis early cognitive impairment neuropsychological assessment modifying factors Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Gromisch ES Dhari Z Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis
description	Elizabeth S Gromisch,1– 4 Zaenab Dhari1,2 1Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, Hartford, CT, USA; 2Department of Rehabilitative Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, USA; 3Department of Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT, USA; 4Department of Neurology, University of Connecticut School of Medicine, Farmington, CT, USACorrespondence: Elizabeth S Gromisch 490 Blue Hills Avenue, Hartford, CT, 06112, USATel +860-714-2154Fax +860-714-8933Email elizabeth.gromisch@trinityhealthofne.orgAbstract: Multiple sclerosis (MS) is a debilitating disease of the central nervous system that is most commonly seen in early to middle adulthood, although it can be diagnosed during childhood or later in life. While cognitive impairment can become more prevalent and severe as the disease progresses, signs of cognitive involvement can be apparent in the early stages of the disease. In this review, we discuss the prevalence and types of cognitive impairment seen in early MS, including the specific measures used to identify them, as well as the challenges in characterizing their frequency and progression. In addition to examining the progression of early cognitive involvement over time, we explore the clinical factors associated with early cognitive involvement, including demographics, level of physical disability, disease modifying therapy use, vocational status, and psychological and physical symptoms. Given the prevalence and functional impact these impairments can have for persons with MS, considerations for clinicians are provided, such as the role of early cognitive screenings and the importance of comprehensive neuropsychological assessments.Keywords: multiple sclerosis, early cognitive impairment, neuropsychological assessment, modifying factors
format	article
author	Gromisch ES Dhari Z
author_facet	Gromisch ES Dhari Z
author_sort	Gromisch ES
title	Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis
title_short	Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis
title_full	Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis
title_fullStr	Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis
title_full_unstemmed	Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis
title_sort	identifying early neuropsychological indicators of cognitive involvement in multiple sclerosis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/46d70a5425f841c18f6f827a3c028345
work_keys_str_mv	AT gromisches identifyingearlyneuropsychologicalindicatorsofcognitiveinvolvementinmultiplesclerosis AT dhariz identifyingearlyneuropsychologicalindicatorsofcognitiveinvolvementinmultiplesclerosis
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Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis

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