Effects of 3% trehalose as an adjuvant treatment after LASIK

Antonio J Mateo Orobia,1–3 Paula Casas Pascual,1,4 José Á Cristóbal Bescós,1 Diana Perez García,1,4 Carlos Peiro Embid,1,4 M Ángeles del Buey Sayas,1,4 Valentyna Korobko Kulikova,1 Noelia Lafuente Ojeda5 1Department of Opht...

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Autores principales:	Mateo Orobia AJ, Casas Pascual P, Cristóbal Bescós JÁ, Perez García D, Peiro Embid C, del Buey Sayas MÁ, Korobko Kulikova V, Lafuente Ojeda N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	dry eye syndrome trehalose hyaluronic acid LASIK osmolarity. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/46d8c87d4fde415a93e661d4b898bc9a
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spelling	oai:doaj.org-article:46d8c87d4fde415a93e661d4b898bc9a2021-12-02T04:18:51ZEffects of 3% trehalose as an adjuvant treatment after LASIK1177-5483https://doaj.org/article/46d8c87d4fde415a93e661d4b898bc9a2017-02-01T00:00:00Zhttps://www.dovepress.com/effects-of-3-trehalose-as-an-adjuvant-treatment-after-lasik-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Antonio J Mateo Orobia,1–3 Paula Casas Pascual,1,4 José Á Cristóbal Bescós,1 Diana Perez García,1,4 Carlos Peiro Embid,1,4 M Ángeles del Buey Sayas,1,4 Valentyna Korobko Kulikova,1 Noelia Lafuente Ojeda5 1Department of Ophthalmology, Hospital Quirón, 2Department of Ophthalmology, Hospital Universitario Miguel Servet, 3Instituto de Investigación Sanitaria de Aragón (IIS), 4Department of Ophthalmology, Hospital Clínico Universitario Lozano-Blesa, 5Department of Anesthesiology, Hospital Universitario Miguel Servet, Zaragoza, Spain Purpose: To evaluate the effect of 3% trehalose as an adjuvant in the standard treatment after laser-assisted in situ keratomileusis.Design: Interventional prospective comparative single-blind study.Setting: Department of Ophthalmology, Hospital Quirón Zaragoza, Spain.Methods: A total of 26 eyes (13 patients) were included, of which 12 eyes (group 1) received conventional treatment with lubricant drops of hyaluronic acid (0.15%) and 14 eyes (group 2) received, additionally, an ophthalmic solution of 3% trehalose. Pre- and postoperative quality-of-life tests and vital stains, tear breakup time, and osmolarity measurements were made.Results: We obtained statistically significant differences between the groups in the Symptom Assessment in Dry Eye test in all visits with respect to severity, and in the postoperative day 1 visit with respect to frequency, in all cases favoring the trehalose treatment. The values of osmolarity were not significantly different between groups. However, we did find significant differences in the Oxford scale in day 90 for the trehalose treatment (P<0.001), and in the National Eye Institute scale in day 30 (P=0.02).Conclusion: The results of this exploratory study indicate that the adjuvant treatment with 3% trehalose could be superior with respect to the standard treatment, with improvements in the objective and subjective parameters of tear quality. Keywords: dry eye syndrome, trehalose, hyaluronic acid, LASIK, osmolarityMateo Orobia AJCasas Pascual PCristóbal Bescós JÁPerez García DPeiro Embid Cdel Buey Sayas MÁKorobko Kulikova VLafuente Ojeda NDove Medical Pressarticledry eye syndrometrehalosehyaluronic acidLASIKosmolarity.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 11, Pp 347-353 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye syndrome trehalose hyaluronic acid LASIK osmolarity. Ophthalmology RE1-994
spellingShingle	dry eye syndrome trehalose hyaluronic acid LASIK osmolarity. Ophthalmology RE1-994 Mateo Orobia AJ Casas Pascual P Cristóbal Bescós JÁ Perez García D Peiro Embid C del Buey Sayas MÁ Korobko Kulikova V Lafuente Ojeda N Effects of 3% trehalose as an adjuvant treatment after LASIK
description	Antonio J Mateo Orobia,1–3 Paula Casas Pascual,1,4 José Á Cristóbal Bescós,1 Diana Perez García,1,4 Carlos Peiro Embid,1,4 M Ángeles del Buey Sayas,1,4 Valentyna Korobko Kulikova,1 Noelia Lafuente Ojeda5 1Department of Ophthalmology, Hospital Quirón, 2Department of Ophthalmology, Hospital Universitario Miguel Servet, 3Instituto de Investigación Sanitaria de Aragón (IIS), 4Department of Ophthalmology, Hospital Clínico Universitario Lozano-Blesa, 5Department of Anesthesiology, Hospital Universitario Miguel Servet, Zaragoza, Spain Purpose: To evaluate the effect of 3% trehalose as an adjuvant in the standard treatment after laser-assisted in situ keratomileusis.Design: Interventional prospective comparative single-blind study.Setting: Department of Ophthalmology, Hospital Quirón Zaragoza, Spain.Methods: A total of 26 eyes (13 patients) were included, of which 12 eyes (group 1) received conventional treatment with lubricant drops of hyaluronic acid (0.15%) and 14 eyes (group 2) received, additionally, an ophthalmic solution of 3% trehalose. Pre- and postoperative quality-of-life tests and vital stains, tear breakup time, and osmolarity measurements were made.Results: We obtained statistically significant differences between the groups in the Symptom Assessment in Dry Eye test in all visits with respect to severity, and in the postoperative day 1 visit with respect to frequency, in all cases favoring the trehalose treatment. The values of osmolarity were not significantly different between groups. However, we did find significant differences in the Oxford scale in day 90 for the trehalose treatment (P<0.001), and in the National Eye Institute scale in day 30 (P=0.02).Conclusion: The results of this exploratory study indicate that the adjuvant treatment with 3% trehalose could be superior with respect to the standard treatment, with improvements in the objective and subjective parameters of tear quality. Keywords: dry eye syndrome, trehalose, hyaluronic acid, LASIK, osmolarity
format	article
author	Mateo Orobia AJ Casas Pascual P Cristóbal Bescós JÁ Perez García D Peiro Embid C del Buey Sayas MÁ Korobko Kulikova V Lafuente Ojeda N
author_facet	Mateo Orobia AJ Casas Pascual P Cristóbal Bescós JÁ Perez García D Peiro Embid C del Buey Sayas MÁ Korobko Kulikova V Lafuente Ojeda N
author_sort	Mateo Orobia AJ
title	Effects of 3% trehalose as an adjuvant treatment after LASIK
title_short	Effects of 3% trehalose as an adjuvant treatment after LASIK
title_full	Effects of 3% trehalose as an adjuvant treatment after LASIK
title_fullStr	Effects of 3% trehalose as an adjuvant treatment after LASIK
title_full_unstemmed	Effects of 3% trehalose as an adjuvant treatment after LASIK
title_sort	effects of 3% trehalose as an adjuvant treatment after lasik
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/46d8c87d4fde415a93e661d4b898bc9a
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Effects of 3% trehalose as an adjuvant treatment after LASIK

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