Asymmetric remote C-H borylation of internal alkenes via alkene isomerization

Sequential alkene isomerization/functionalization enables enantioselective transformations of remote C–H bonds. Here, the authors report a chiral cobalt catalytic system for the highly enantioselective, remote C–H borylation of internal alkenes via an isomerization/hydroboration sequence.

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Detalles Bibliográficos
Autores principales: Xu Chen, Zhaoyang Cheng, Jun Guo, Zhan Lu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/46dca3b2e3ec4606821b361f5f6543aa
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Sumario:Sequential alkene isomerization/functionalization enables enantioselective transformations of remote C–H bonds. Here, the authors report a chiral cobalt catalytic system for the highly enantioselective, remote C–H borylation of internal alkenes via an isomerization/hydroboration sequence.