Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder

Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder

Tomoya Takeda,1 Satsuki Sumitani,2 Sayo Hamatani,1 Yosuke Yokose,3 Megumi Shikata,4 Tetsuro Ohmori5 1Department of Psychiatry, Tokushima University Hospital, 2Department of Support for Students with Special Needs, Institute of Biomedical Sciences, Tokushima University Graduate School, 3Taoka Higash...

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Autores principales: Takeda T, Sumitani S, Hamatani S, Yokose Y, Shikata M, Ohmori T
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2017
Materias:
obsessive-compulsive disorder
drug response
near infrared spectroscopy
Stroop task
verbal fluency test
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Acceso en línea:https://doaj.org/article/46e2f1de7b8547b29aff2b59206bd66f
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spelling oai:doaj.org-article:46e2f1de7b8547b29aff2b59206bd66f2021-12-02T04:18:28ZPrefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder1178-2021https://doaj.org/article/46e2f1de7b8547b29aff2b59206bd66f2017-02-01T00:00:00Zhttps://www.dovepress.com/prefrontal-cortex-activation-during-neuropsychological-tasks-might-pre-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Tomoya Takeda,1 Satsuki Sumitani,2 Sayo Hamatani,1 Yosuke Yokose,3 Megumi Shikata,4 Tetsuro Ohmori5 1Department of Psychiatry, Tokushima University Hospital, 2Department of Support for Students with Special Needs, Institute of Biomedical Sciences, Tokushima University Graduate School, 3Taoka Higashi Hospital, Tokushima, 4Department of Psychiatry, Ibogawa Hospital, Tatsuno, 5Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan Objective: We investigated oxyhemoglobin change in the prefrontal cortex (PFC) of patients with obsessive–compulsive disorder (OCD) who showed different responses to pharmacotherapy during neuropsychological tasks with near-infrared spectroscopy. Subjects and methods: A total of 42 patients with OCD (mean age: 35.6±9.6 years, 14 men, 28 women) and healthy control subjects (mean age: 35.4±9.7 years, 13 men, 29 women) were selected. Patients with OCD were divided into three groups (responders to selective serotonin-reuptake inhibitors (SSRIs), responders to SSRIs with antipsychotics, and nonresponders to SSRIs and SSRIs with antipsychotics) based on pharmacological response. We investigated oxyhemoglobin change in the PFC of subjects during Stroop tasks and a verbal fluency test with near-infrared spectroscopy. Results: Responders to SSRIs showed smaller activation compared to control subjects during the Stroop incongruent task and verbal fluency test, but not during the Stroop congruent task. In contrast, responders to SSRIs with antipsychotics showed smaller activation compared to control subjects during all three tasks. Conclusion: Our results suggest that activation of the PFC during Stroop tasks might predict responses to pharmacotherapy of patients with OCD. Keywords: obsessive–compulsive disorder, pharmacotherapy, near-infrared spectroscopy, Stroop task, verbal fluency testTakeda TSumitani SHamatani SYokose YShikata MOhmori TDove Medical Pressarticleobsessive-compulsive disorderdrug responsenear infrared spectroscopyStroop taskverbal fluency testNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 577-583 (2017)
institution DOAJ
collection DOAJ
language EN
topic obsessive-compulsive disorder
drug response
near infrared spectroscopy
Stroop task
verbal fluency test
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
spellingShingle obsessive-compulsive disorder
drug response
near infrared spectroscopy
Stroop task
verbal fluency test
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Neurology. Diseases of the nervous system
RC346-429
Takeda T
Sumitani S
Hamatani S
Yokose Y
Shikata M
Ohmori T
Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder
description Tomoya Takeda,1 Satsuki Sumitani,2 Sayo Hamatani,1 Yosuke Yokose,3 Megumi Shikata,4 Tetsuro Ohmori5 1Department of Psychiatry, Tokushima University Hospital, 2Department of Support for Students with Special Needs, Institute of Biomedical Sciences, Tokushima University Graduate School, 3Taoka Higashi Hospital, Tokushima, 4Department of Psychiatry, Ibogawa Hospital, Tatsuno, 5Department of Psychiatry, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan Objective: We investigated oxyhemoglobin change in the prefrontal cortex (PFC) of patients with obsessive–compulsive disorder (OCD) who showed different responses to pharmacotherapy during neuropsychological tasks with near-infrared spectroscopy. Subjects and methods: A total of 42 patients with OCD (mean age: 35.6±9.6 years, 14 men, 28 women) and healthy control subjects (mean age: 35.4±9.7 years, 13 men, 29 women) were selected. Patients with OCD were divided into three groups (responders to selective serotonin-reuptake inhibitors (SSRIs), responders to SSRIs with antipsychotics, and nonresponders to SSRIs and SSRIs with antipsychotics) based on pharmacological response. We investigated oxyhemoglobin change in the PFC of subjects during Stroop tasks and a verbal fluency test with near-infrared spectroscopy. Results: Responders to SSRIs showed smaller activation compared to control subjects during the Stroop incongruent task and verbal fluency test, but not during the Stroop congruent task. In contrast, responders to SSRIs with antipsychotics showed smaller activation compared to control subjects during all three tasks. Conclusion: Our results suggest that activation of the PFC during Stroop tasks might predict responses to pharmacotherapy of patients with OCD. Keywords: obsessive–compulsive disorder, pharmacotherapy, near-infrared spectroscopy, Stroop task, verbal fluency test
format article
author Takeda T
Sumitani S
Hamatani S
Yokose Y
Shikata M
Ohmori T
author_facet Takeda T
Sumitani S
Hamatani S
Yokose Y
Shikata M
Ohmori T
author_sort Takeda T
title Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder
title_short Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder
title_full Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder
title_fullStr Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder
title_full_unstemmed Prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder
title_sort prefrontal cortex activation during neuropsychological tasks might predict response to pharmacotherapy in patients with obsessive–compulsive disorder
publisher Dove Medical Press
publishDate 2017
url https://doaj.org/article/46e2f1de7b8547b29aff2b59206bd66f
work_keys_str_mv AT takedat prefrontalcortexactivationduringneuropsychologicaltasksmightpredictresponsetopharmacotherapyinpatientswithobsessivendashcompulsivedisorder
AT sumitanis prefrontalcortexactivationduringneuropsychologicaltasksmightpredictresponsetopharmacotherapyinpatientswithobsessivendashcompulsivedisorder
AT hamatanis prefrontalcortexactivationduringneuropsychologicaltasksmightpredictresponsetopharmacotherapyinpatientswithobsessivendashcompulsivedisorder
AT yokosey prefrontalcortexactivationduringneuropsychologicaltasksmightpredictresponsetopharmacotherapyinpatientswithobsessivendashcompulsivedisorder
AT shikatam prefrontalcortexactivationduringneuropsychologicaltasksmightpredictresponsetopharmacotherapyinpatientswithobsessivendashcompulsivedisorder
AT ohmorit prefrontalcortexactivationduringneuropsychologicaltasksmightpredictresponsetopharmacotherapyinpatientswithobsessivendashcompulsivedisorder
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