Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study

Wanqing Liu,1 Chuanlong Cao,2 Bing Hu,1 Danyang Li,1 Yumei Sun,1 Jianlin Wu,1 Qing Zhang1 1Department of Radiology, Afﬁliated Zhongshan Hospital of Dalian University, Dalian 116001, People’s Republic of China; 2Department of Radiology, Afﬁliated Xinhua Hospital of Dalian University, Dalian...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Liu W, Cao C, Hu B, Li D, Sun Y, Wu J, Zhang Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	obstructive sleep apnea-hypopnea syndrome cognitive impairment connectome graph theory gray matter volume Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/46e61764674c401f80a871de24a76c40
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46e61764674c401f80a871de24a76c40
record_format	dspace
spelling	oai:doaj.org-article:46e61764674c401f80a871de24a76c402021-12-02T11:36:52ZTopological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study1179-1608https://doaj.org/article/46e61764674c401f80a871de24a76c402020-06-01T00:00:00Zhttps://www.dovepress.com/topological-regularization-of-networks-in-adult-patients-with-moderate-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Wanqing Liu,1 Chuanlong Cao,2 Bing Hu,1 Danyang Li,1 Yumei Sun,1 Jianlin Wu,1 Qing Zhang1 1Department of Radiology, Afﬁliated Zhongshan Hospital of Dalian University, Dalian 116001, People’s Republic of China; 2Department of Radiology, Afﬁliated Xinhua Hospital of Dalian University, Dalian 116001, People’s Republic of ChinaCorrespondence: Qing ZhangDepartment of Radiology, Afﬁliated Zhongshan Hospital of Dalian University, No. 6, Jiefang Street, Zhongshan District, Dalian, Liaoning, People’s Republic of ChinaEmail zhangqingsmile@163.comObjective: Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) exhibit neurocognitive impairments; however, the neuroimaging mechanism of neurocognitive impairments remains unclear. The aim of this study was to understand the neuroimaging mechanism in adult patients with moderate-to-severe OSAHS, from the perspective of the connectome.Patients and Methods: Thirty-one untreated patients with moderate-to-severe OSAHS (mean age: 41.23± 8.22) were compared with 26 good sleepers (GS) (mean age: 39.50± 7.92) matched according to age, gender, handedness, and education level. All subjects underwent thin-slice T1WI scanning of the skull using a 3.0T MRI. Then, a large-scale structural covariance network was constructed based on the gray matter volume extracted from the structural MRI. Graph theory was then used to determine the topological changes in the structural covariance network of OSAHS patients.Results: Although small-world networks were retained,the structural covariance network exhibited topological irregularities in regular architecture as evidenced by an increase in the clustering coefficient (p=0.009), transfer coefficient (p=0.029) and local efficiency (p=0.031), and a local increase in the shortest path length (p< 0.05) compared with the GS group. Locally, OSAHS patients showed a decrease in nodal betweenness and degree in the left inferior parietal gyrus, left angular gyrus and right anterior cingulate cortex compared with the GS group (p< 0.05, uncorrected). In addition, the resistance of structural covariance networks in OSAHS patients to random fault is significantly lower than that of the GS group (p=0.044).Conclusion: Structural covariance networks are abnormal in terms of multiple network parameters, which provide network-level insight into the neuroimaging mechanism of cognitive impairments in adult OSAHS patients.Keywords: obstructive sleep apnea-hypopnea syndrome, cognitive impairment, connectome, graph theory, gray matter volumeLiu WCao CHu BLi DSun YWu JZhang QDove Medical Pressarticleobstructive sleep apnea-hypopnea syndromecognitive impairmentconnectomegraph theorygray matter volumePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 12, Pp 333-345 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	obstructive sleep apnea-hypopnea syndrome cognitive impairment connectome graph theory gray matter volume Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	obstructive sleep apnea-hypopnea syndrome cognitive impairment connectome graph theory gray matter volume Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Liu W Cao C Hu B Li D Sun Y Wu J Zhang Q Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study
description	Wanqing Liu,1 Chuanlong Cao,2 Bing Hu,1 Danyang Li,1 Yumei Sun,1 Jianlin Wu,1 Qing Zhang1 1Department of Radiology, Afﬁliated Zhongshan Hospital of Dalian University, Dalian 116001, People’s Republic of China; 2Department of Radiology, Afﬁliated Xinhua Hospital of Dalian University, Dalian 116001, People’s Republic of ChinaCorrespondence: Qing ZhangDepartment of Radiology, Afﬁliated Zhongshan Hospital of Dalian University, No. 6, Jiefang Street, Zhongshan District, Dalian, Liaoning, People’s Republic of ChinaEmail zhangqingsmile@163.comObjective: Patients with obstructive sleep apnea-hypopnea syndrome (OSAHS) exhibit neurocognitive impairments; however, the neuroimaging mechanism of neurocognitive impairments remains unclear. The aim of this study was to understand the neuroimaging mechanism in adult patients with moderate-to-severe OSAHS, from the perspective of the connectome.Patients and Methods: Thirty-one untreated patients with moderate-to-severe OSAHS (mean age: 41.23± 8.22) were compared with 26 good sleepers (GS) (mean age: 39.50± 7.92) matched according to age, gender, handedness, and education level. All subjects underwent thin-slice T1WI scanning of the skull using a 3.0T MRI. Then, a large-scale structural covariance network was constructed based on the gray matter volume extracted from the structural MRI. Graph theory was then used to determine the topological changes in the structural covariance network of OSAHS patients.Results: Although small-world networks were retained,the structural covariance network exhibited topological irregularities in regular architecture as evidenced by an increase in the clustering coefficient (p=0.009), transfer coefficient (p=0.029) and local efficiency (p=0.031), and a local increase in the shortest path length (p< 0.05) compared with the GS group. Locally, OSAHS patients showed a decrease in nodal betweenness and degree in the left inferior parietal gyrus, left angular gyrus and right anterior cingulate cortex compared with the GS group (p< 0.05, uncorrected). In addition, the resistance of structural covariance networks in OSAHS patients to random fault is significantly lower than that of the GS group (p=0.044).Conclusion: Structural covariance networks are abnormal in terms of multiple network parameters, which provide network-level insight into the neuroimaging mechanism of cognitive impairments in adult OSAHS patients.Keywords: obstructive sleep apnea-hypopnea syndrome, cognitive impairment, connectome, graph theory, gray matter volume
format	article
author	Liu W Cao C Hu B Li D Sun Y Wu J Zhang Q
author_facet	Liu W Cao C Hu B Li D Sun Y Wu J Zhang Q
author_sort	Liu W
title	Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study
title_short	Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study
title_full	Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study
title_fullStr	Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study
title_full_unstemmed	Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study
title_sort	topological regularization of networks in adult patients with moderate-to-severe obstructive sleep apnea-hypopnea syndrome: a structural mri study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/46e61764674c401f80a871de24a76c40
work_keys_str_mv	AT liuw topologicalregularizationofnetworksinadultpatientswithmoderatetosevereobstructivesleepapneahypopneasyndromeastructuralmristudy AT caoc topologicalregularizationofnetworksinadultpatientswithmoderatetosevereobstructivesleepapneahypopneasyndromeastructuralmristudy AT hub topologicalregularizationofnetworksinadultpatientswithmoderatetosevereobstructivesleepapneahypopneasyndromeastructuralmristudy AT lid topologicalregularizationofnetworksinadultpatientswithmoderatetosevereobstructivesleepapneahypopneasyndromeastructuralmristudy AT suny topologicalregularizationofnetworksinadultpatientswithmoderatetosevereobstructivesleepapneahypopneasyndromeastructuralmristudy AT wuj topologicalregularizationofnetworksinadultpatientswithmoderatetosevereobstructivesleepapneahypopneasyndromeastructuralmristudy AT zhangq topologicalregularizationofnetworksinadultpatientswithmoderatetosevereobstructivesleepapneahypopneasyndromeastructuralmristudy
_version_	1718395755249532928

Topological Regularization of Networks in Adult Patients with Moderate-to-Severe Obstructive Sleep Apnea-Hypopnea Syndrome: A Structural MRI Study

Ejemplares similares