The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

Centromeres are the chromosomal domains that regulate assembly of the components required for chromosome separation. Here the authors review how centromeres are a potential source of genome instability and link centromere aberrations and rearrangements to human diseases such as cancer.

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Detalles Bibliográficos
Autores principales:	V. Barra, D. Fachinetti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46e6354e186b4bcfbebd09f24d95c255
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spelling	oai:doaj.org-article:46e6354e186b4bcfbebd09f24d95c2552021-12-02T14:41:28ZThe dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA10.1038/s41467-018-06545-y2041-1723https://doaj.org/article/46e6354e186b4bcfbebd09f24d95c2552018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06545-yhttps://doaj.org/toc/2041-1723Centromeres are the chromosomal domains that regulate assembly of the components required for chromosome separation. Here the authors review how centromeres are a potential source of genome instability and link centromere aberrations and rearrangements to human diseases such as cancer.V. BarraD. FachinettiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q V. Barra D. Fachinetti The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
description	Centromeres are the chromosomal domains that regulate assembly of the components required for chromosome separation. Here the authors review how centromeres are a potential source of genome instability and link centromere aberrations and rearrangements to human diseases such as cancer.
format	article
author	V. Barra D. Fachinetti
author_facet	V. Barra D. Fachinetti
author_sort	V. Barra
title	The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_short	The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_full	The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_fullStr	The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_full_unstemmed	The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA
title_sort	dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric dna
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/46e6354e186b4bcfbebd09f24d95c255
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The dark side of centromeres: types, causes and consequences of structural abnormalities implicating centromeric DNA

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