Cystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients

Aim. To compare kidney disease markers: glomerular filtration rate (GFR), calculated upon creatinine and cystatin C, urinary cystatin C, collagen type IV and albumin in type 2 diabetic patients with normal and moderately reduced renal function. Materials and methods. 56 patients, aged 43?70 years,...

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Autores principales:	Vadim Valer'evich Klimontov, Nadezhda Valentinovna Eremenko, Natalya Evgen'evna Myakina, Olga Nikolaevna Fazullina
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2015
Materias:	type 2 diabetes chronic kidney disease glomerular filtration rate cystatin c type iv collagen Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/46e6e78d41104016ba10b05648e4fca9
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spelling	oai:doaj.org-article:46e6e78d41104016ba10b05648e4fca92021-11-14T09:00:19ZCystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients2072-03512072-037810.14341/DM2015187-93https://doaj.org/article/46e6e78d41104016ba10b05648e4fca92015-03-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/6701https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Aim. To compare kidney disease markers: glomerular filtration rate (GFR), calculated upon creatinine and cystatin C, urinary cystatin C, collagen type IV and albumin in type 2 diabetic patients with normal and moderately reduced renal function. Materials and methods. 56 patients, aged 43?70 years, and 16 healthy controls, aged 40-72 years, were included in the study. GFR was calculated by equations based on creatinine (CKD-EPIcreat), cystatin C (CKD-EPIcys) or both markers (CKD-EPIcreat-cys). Serum and urinary cystatin C was measured by immunoturbidimetric method, urinary albumin, albumin excretion rate (AER) and collagen type IV excretion was determined by ELISA. The body composition was investigated in 24 patients by dual-energy X-ray absorptiometry. Results. In diabetic patients serum cystatin C level correlated positively with age (r=0.37), GFR calculated by CKD-EPIcreat (r=-0.43) and fat mass percentage (r=0.55). There was a positive correlation between GFR calculated by the CKD-EPIcys and GFR by CKD-EPIcreat (r=0.48). In multiple regression analysis the percentage of body fat influenced the GFR calculated by CKD-EPIcys or CKD-EPIcreat-cys. No correlation between urinary cystatin C and serum cystatin C level, GFR and AER was found. Collagen type IV excretion was increased in patients with decreased GFR, compared to those with normal GFR (p=0.002). Urinary collagen type IV correlated with both GFR and AER (r=-0.28 and r=0.47). Conclusion. The measurement of serum cystatin C with calculation of GFR by CKD-EPIcys and CKD-EPIcreat-cys, in addition to the CKD-EPIcreat, increases the accuracy of CKD diagnostics in type 2 diabetic patients. However, obesity and particularly body fat mass affect the results of estimation of GFR based on cystatin C. The increase in urinary collagen type IV, but not in cystatin C excretion, is related to GFR decline and AER elevation in these patients.Vadim Valer'evich KlimontovNadezhda Valentinovna EremenkoNatalya Evgen'evna MyakinaOlga Nikolaevna FazullinaEndocrinology Research Centrearticletype 2 diabeteschronic kidney diseaseglomerular filtration ratecystatin ctype iv collagenNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 18, Iss 1, Pp 87-93 (2015)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes chronic kidney disease glomerular filtration rate cystatin c type iv collagen Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes chronic kidney disease glomerular filtration rate cystatin c type iv collagen Nutritional diseases. Deficiency diseases RC620-627 Vadim Valer'evich Klimontov Nadezhda Valentinovna Eremenko Natalya Evgen'evna Myakina Olga Nikolaevna Fazullina Cystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients
description	Aim. To compare kidney disease markers: glomerular filtration rate (GFR), calculated upon creatinine and cystatin C, urinary cystatin C, collagen type IV and albumin in type 2 diabetic patients with normal and moderately reduced renal function. Materials and methods. 56 patients, aged 43?70 years, and 16 healthy controls, aged 40-72 years, were included in the study. GFR was calculated by equations based on creatinine (CKD-EPIcreat), cystatin C (CKD-EPIcys) or both markers (CKD-EPIcreat-cys). Serum and urinary cystatin C was measured by immunoturbidimetric method, urinary albumin, albumin excretion rate (AER) and collagen type IV excretion was determined by ELISA. The body composition was investigated in 24 patients by dual-energy X-ray absorptiometry. Results. In diabetic patients serum cystatin C level correlated positively with age (r=0.37), GFR calculated by CKD-EPIcreat (r=-0.43) and fat mass percentage (r=0.55). There was a positive correlation between GFR calculated by the CKD-EPIcys and GFR by CKD-EPIcreat (r=0.48). In multiple regression analysis the percentage of body fat influenced the GFR calculated by CKD-EPIcys or CKD-EPIcreat-cys. No correlation between urinary cystatin C and serum cystatin C level, GFR and AER was found. Collagen type IV excretion was increased in patients with decreased GFR, compared to those with normal GFR (p=0.002). Urinary collagen type IV correlated with both GFR and AER (r=-0.28 and r=0.47). Conclusion. The measurement of serum cystatin C with calculation of GFR by CKD-EPIcys and CKD-EPIcreat-cys, in addition to the CKD-EPIcreat, increases the accuracy of CKD diagnostics in type 2 diabetic patients. However, obesity and particularly body fat mass affect the results of estimation of GFR based on cystatin C. The increase in urinary collagen type IV, but not in cystatin C excretion, is related to GFR decline and AER elevation in these patients.
format	article
author	Vadim Valer'evich Klimontov Nadezhda Valentinovna Eremenko Natalya Evgen'evna Myakina Olga Nikolaevna Fazullina
author_facet	Vadim Valer'evich Klimontov Nadezhda Valentinovna Eremenko Natalya Evgen'evna Myakina Olga Nikolaevna Fazullina
author_sort	Vadim Valer'evich Klimontov
title	Cystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients
title_short	Cystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients
title_full	Cystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients
title_fullStr	Cystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients
title_full_unstemmed	Cystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients
title_sort	cystatin c and collagen type iv in diagnostics of chronic kidney disease in type 2 diabetic patients
publisher	Endocrinology Research Centre
publishDate	2015
url	https://doaj.org/article/46e6e78d41104016ba10b05648e4fca9
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Cystatin C and collagen type IV in diagnostics of chronic kidney disease in type 2 diabetic patients

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