The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting

Introduction: Atherosclerosis (AS), as a significant cardiovascular disease, is the main factor of death in the world. There has been an association between plasma lipoproteins and AS. Reverse cholesterol transfer (RCT), in which ATP binding cassette (ABC) adenosine triphosphate transporters are maj...

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Autores principales:	Fahimeh Yonesi, Amir Rashidlamir, Rambod Khajei, Ameneh Barjaste Yazdi
Formato:	article
Lenguaje:	EN
Publicado:	Zabol University of Medical sciences 2020
Materias:	combined training coronary artery bypass grafting abcg4 interleukin-4 Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/46ec0e780d3143c7b8304e0061a7f3fb
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spelling	oai:doaj.org-article:46ec0e780d3143c7b8304e0061a7f3fb2021-11-17T09:54:52ZThe Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting2476-664X10.34172/ijbsm.2020.26https://doaj.org/article/46ec0e780d3143c7b8304e0061a7f3fb2020-12-01T00:00:00Zhttp://ijbsm.zbmu.ac.ir/PDF/ijbsm-21475https://doaj.org/toc/2476-664XIntroduction: Atherosclerosis (AS), as a significant cardiovascular disease, is the main factor of death in the world. There has been an association between plasma lipoproteins and AS. Reverse cholesterol transfer (RCT), in which ATP binding cassette (ABC) adenosine triphosphate transporters are major contributors, prevents AS incidence by reducing the accumulation of cholesterol on the walls of blood vessels. Our purpose was to investigate the effect of a combination training session on the gene expression of ABCG4 and plasma level of interleukin-4 (IL-4) in nucleated blood cells of middle-aged men after coronary artery bypass grafting (CABG). Methods: The statistical population consisted of 20 middle-aged men who had previously undergone CABG. After selection, these individuals were randomly divided into two groups of n=10; control and combined exercise. At the beginning and end of training sessions, blood samples were obtained to isolate mononuclear cells and extract mRNA. Real-time polymerase chain reaction (PCR) was used for gene expression analysis, and IL-4 was determined by ELISA. SPSS software version 16 was used for data analysis. Results: The training period remarkably increased ABCG4 expression and IL-4 plasma level compared to the control group. Conclusion: Combined training, as a part of cardiac rehabilitation in those undergoing CABG may improve the RCT process by affecting the gene expression of ABCG4 and IL-4 production, which are involved in fat burning and metabolism.Fahimeh YonesiAmir RashidlamirRambod KhajeiAmeneh Barjaste YazdiZabol University of Medical sciencesarticlecombined training coronary artery bypass grafting abcg4 interleukin-4 Medicine (General)R5-920ENInternational Journal of Basic Science in Medicine, Vol 5, Iss 4, Pp 147-154 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	combined training coronary artery bypass grafting abcg4 interleukin-4 Medicine (General) R5-920
spellingShingle	combined training coronary artery bypass grafting abcg4 interleukin-4 Medicine (General) R5-920 Fahimeh Yonesi Amir Rashidlamir Rambod Khajei Ameneh Barjaste Yazdi The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting
description	Introduction: Atherosclerosis (AS), as a significant cardiovascular disease, is the main factor of death in the world. There has been an association between plasma lipoproteins and AS. Reverse cholesterol transfer (RCT), in which ATP binding cassette (ABC) adenosine triphosphate transporters are major contributors, prevents AS incidence by reducing the accumulation of cholesterol on the walls of blood vessels. Our purpose was to investigate the effect of a combination training session on the gene expression of ABCG4 and plasma level of interleukin-4 (IL-4) in nucleated blood cells of middle-aged men after coronary artery bypass grafting (CABG). Methods: The statistical population consisted of 20 middle-aged men who had previously undergone CABG. After selection, these individuals were randomly divided into two groups of n=10; control and combined exercise. At the beginning and end of training sessions, blood samples were obtained to isolate mononuclear cells and extract mRNA. Real-time polymerase chain reaction (PCR) was used for gene expression analysis, and IL-4 was determined by ELISA. SPSS software version 16 was used for data analysis. Results: The training period remarkably increased ABCG4 expression and IL-4 plasma level compared to the control group. Conclusion: Combined training, as a part of cardiac rehabilitation in those undergoing CABG may improve the RCT process by affecting the gene expression of ABCG4 and IL-4 production, which are involved in fat burning and metabolism.
format	article
author	Fahimeh Yonesi Amir Rashidlamir Rambod Khajei Ameneh Barjaste Yazdi
author_facet	Fahimeh Yonesi Amir Rashidlamir Rambod Khajei Ameneh Barjaste Yazdi
author_sort	Fahimeh Yonesi
title	The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting
title_short	The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting
title_full	The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting
title_fullStr	The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting
title_full_unstemmed	The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting
title_sort	effect of combined training courses on the expression of abcg4 gene and interleukin-4 plasma level in middle-aged men undergoing coronary artery bypass grafting
publisher	Zabol University of Medical sciences
publishDate	2020
url	https://doaj.org/article/46ec0e780d3143c7b8304e0061a7f3fb
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The Effect of Combined Training Courses on the Expression of ABCG4 Gene and Interleukin-4 Plasma Level in Middle-Aged Men Undergoing Coronary Artery Bypass Grafting

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