SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation

Human induced pluripotent stem cells (hiPSCs) generate all cell types in the body, but different lines can differ in their potential. Here, the authors determine that higher endogenous levels of SALL3 in hiPSCs lead to ectoderm differentiation bias and reduced mesoderm/endoderm due to DNMT3B mediate...

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Autores principales:	Takuya Kuroda, Satoshi Yasuda, Shiori Tachi, Satoko Matsuyama, Shinji Kusakawa, Keiko Tano, Takumi Miura, Akifumi Matsuyama, Yoji Sato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46ec5862781d440890248a463ec73ca6
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spelling	oai:doaj.org-article:46ec5862781d440890248a463ec73ca62021-12-02T17:01:52ZSALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation10.1038/s41467-019-09511-42041-1723https://doaj.org/article/46ec5862781d440890248a463ec73ca62019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09511-4https://doaj.org/toc/2041-1723Human induced pluripotent stem cells (hiPSCs) generate all cell types in the body, but different lines can differ in their potential. Here, the authors determine that higher endogenous levels of SALL3 in hiPSCs lead to ectoderm differentiation bias and reduced mesoderm/endoderm due to DNMT3B mediated DNA methylation.Takuya KurodaSatoshi YasudaShiori TachiSatoko MatsuyamaShinji KusakawaKeiko TanoTakumi MiuraAkifumi MatsuyamaYoji SatoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Takuya Kuroda Satoshi Yasuda Shiori Tachi Satoko Matsuyama Shinji Kusakawa Keiko Tano Takumi Miura Akifumi Matsuyama Yoji Sato SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation
description	Human induced pluripotent stem cells (hiPSCs) generate all cell types in the body, but different lines can differ in their potential. Here, the authors determine that higher endogenous levels of SALL3 in hiPSCs lead to ectoderm differentiation bias and reduced mesoderm/endoderm due to DNMT3B mediated DNA methylation.
format	article
author	Takuya Kuroda Satoshi Yasuda Shiori Tachi Satoko Matsuyama Shinji Kusakawa Keiko Tano Takumi Miura Akifumi Matsuyama Yoji Sato
author_facet	Takuya Kuroda Satoshi Yasuda Shiori Tachi Satoko Matsuyama Shinji Kusakawa Keiko Tano Takumi Miura Akifumi Matsuyama Yoji Sato
author_sort	Takuya Kuroda
title	SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation
title_short	SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation
title_full	SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation
title_fullStr	SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation
title_full_unstemmed	SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation
title_sort	sall3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/46ec5862781d440890248a463ec73ca6
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SALL3 expression balance underlies lineage biases in human induced pluripotent stem cell differentiation

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