TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling

TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling

TMCO1 is a recently described endoplasmic reticular Ca2+ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca2+ at the ER surface with the posttranslational modification of RUNX2.

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Detalles Bibliográficos
Autores principales: Jianwei Li, Caizhi Liu, Yuheng Li, Qiaoxia Zheng, Youjia Xu, Beibei Liu, Weijia Sun, Yuan Li, Shuhui Ji, Mingwei Liu, Jing Zhang, Dingsheng Zhao, Ruikai Du, Zizhong Liu, Guohui Zhong, Cuiwei Sun, Yanqing Wang, Jinping Song, Shu Zhang, Jun Qin, Shukuan Ling, Xianhua Wang, Yingxian Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
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Acceso en línea:https://doaj.org/article/46eec4092ce9465eabd30d54fc3baf63
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Sumario:TMCO1 is a recently described endoplasmic reticular Ca2+ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca2+ at the ER surface with the posttranslational modification of RUNX2.

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