TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling

TMCO1 is a recently described endoplasmic reticular Ca2+ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca2+ at the ER surface with the posttranslational modification of RUNX2.

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Autores principales: Jianwei Li, Caizhi Liu, Yuheng Li, Qiaoxia Zheng, Youjia Xu, Beibei Liu, Weijia Sun, Yuan Li, Shuhui Ji, Mingwei Liu, Jing Zhang, Dingsheng Zhao, Ruikai Du, Zizhong Liu, Guohui Zhong, Cuiwei Sun, Yanqing Wang, Jinping Song, Shu Zhang, Jun Qin, Shukuan Ling, Xianhua Wang, Yingxian Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/46eec4092ce9465eabd30d54fc3baf63
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spelling oai:doaj.org-article:46eec4092ce9465eabd30d54fc3baf632021-12-02T17:01:45ZTMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling10.1038/s41467-019-09653-52041-1723https://doaj.org/article/46eec4092ce9465eabd30d54fc3baf632019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09653-5https://doaj.org/toc/2041-1723TMCO1 is a recently described endoplasmic reticular Ca2+ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca2+ at the ER surface with the posttranslational modification of RUNX2.Jianwei LiCaizhi LiuYuheng LiQiaoxia ZhengYoujia XuBeibei LiuWeijia SunYuan LiShuhui JiMingwei LiuJing ZhangDingsheng ZhaoRuikai DuZizhong LiuGuohui ZhongCuiwei SunYanqing WangJinping SongShu ZhangJun QinShukuan LingXianhua WangYingxian LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jianwei Li
Caizhi Liu
Yuheng Li
Qiaoxia Zheng
Youjia Xu
Beibei Liu
Weijia Sun
Yuan Li
Shuhui Ji
Mingwei Liu
Jing Zhang
Dingsheng Zhao
Ruikai Du
Zizhong Liu
Guohui Zhong
Cuiwei Sun
Yanqing Wang
Jinping Song
Shu Zhang
Jun Qin
Shukuan Ling
Xianhua Wang
Yingxian Li
TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling
description TMCO1 is a recently described endoplasmic reticular Ca2+ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca2+ at the ER surface with the posttranslational modification of RUNX2.
format article
author Jianwei Li
Caizhi Liu
Yuheng Li
Qiaoxia Zheng
Youjia Xu
Beibei Liu
Weijia Sun
Yuan Li
Shuhui Ji
Mingwei Liu
Jing Zhang
Dingsheng Zhao
Ruikai Du
Zizhong Liu
Guohui Zhong
Cuiwei Sun
Yanqing Wang
Jinping Song
Shu Zhang
Jun Qin
Shukuan Ling
Xianhua Wang
Yingxian Li
author_facet Jianwei Li
Caizhi Liu
Yuheng Li
Qiaoxia Zheng
Youjia Xu
Beibei Liu
Weijia Sun
Yuan Li
Shuhui Ji
Mingwei Liu
Jing Zhang
Dingsheng Zhao
Ruikai Du
Zizhong Liu
Guohui Zhong
Cuiwei Sun
Yanqing Wang
Jinping Song
Shu Zhang
Jun Qin
Shukuan Ling
Xianhua Wang
Yingxian Li
author_sort Jianwei Li
title TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling
title_short TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling
title_full TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling
title_fullStr TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling
title_full_unstemmed TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling
title_sort tmco1-mediated ca2+ leak underlies osteoblast functions via camkii signaling
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/46eec4092ce9465eabd30d54fc3baf63
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