TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling
TMCO1 is a recently described endoplasmic reticular Ca2+ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca2+ at the ER surface with the posttranslational modification of RUNX2.
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Nature Portfolio
2019
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oai:doaj.org-article:46eec4092ce9465eabd30d54fc3baf632021-12-02T17:01:45ZTMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling10.1038/s41467-019-09653-52041-1723https://doaj.org/article/46eec4092ce9465eabd30d54fc3baf632019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09653-5https://doaj.org/toc/2041-1723TMCO1 is a recently described endoplasmic reticular Ca2+ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca2+ at the ER surface with the posttranslational modification of RUNX2.Jianwei LiCaizhi LiuYuheng LiQiaoxia ZhengYoujia XuBeibei LiuWeijia SunYuan LiShuhui JiMingwei LiuJing ZhangDingsheng ZhaoRuikai DuZizhong LiuGuohui ZhongCuiwei SunYanqing WangJinping SongShu ZhangJun QinShukuan LingXianhua WangYingxian LiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Jianwei Li Caizhi Liu Yuheng Li Qiaoxia Zheng Youjia Xu Beibei Liu Weijia Sun Yuan Li Shuhui Ji Mingwei Liu Jing Zhang Dingsheng Zhao Ruikai Du Zizhong Liu Guohui Zhong Cuiwei Sun Yanqing Wang Jinping Song Shu Zhang Jun Qin Shukuan Ling Xianhua Wang Yingxian Li TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling |
| description |
TMCO1 is a recently described endoplasmic reticular Ca2+ channel. Here, the authors show it is important for osteoblast function and bone formation in mice, and identify a novel pathway linking local increases in Ca2+ at the ER surface with the posttranslational modification of RUNX2. |
| format |
article |
| author |
Jianwei Li Caizhi Liu Yuheng Li Qiaoxia Zheng Youjia Xu Beibei Liu Weijia Sun Yuan Li Shuhui Ji Mingwei Liu Jing Zhang Dingsheng Zhao Ruikai Du Zizhong Liu Guohui Zhong Cuiwei Sun Yanqing Wang Jinping Song Shu Zhang Jun Qin Shukuan Ling Xianhua Wang Yingxian Li |
| author_facet |
Jianwei Li Caizhi Liu Yuheng Li Qiaoxia Zheng Youjia Xu Beibei Liu Weijia Sun Yuan Li Shuhui Ji Mingwei Liu Jing Zhang Dingsheng Zhao Ruikai Du Zizhong Liu Guohui Zhong Cuiwei Sun Yanqing Wang Jinping Song Shu Zhang Jun Qin Shukuan Ling Xianhua Wang Yingxian Li |
| author_sort |
Jianwei Li |
| title |
TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling |
| title_short |
TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling |
| title_full |
TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling |
| title_fullStr |
TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling |
| title_full_unstemmed |
TMCO1-mediated Ca2+ leak underlies osteoblast functions via CaMKII signaling |
| title_sort |
tmco1-mediated ca2+ leak underlies osteoblast functions via camkii signaling |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/46eec4092ce9465eabd30d54fc3baf63 |
| work_keys_str_mv |
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