Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children

Background: Asthma is a common disease especially in kids. The development of asthma symptoms appears to involve a combination of genetic predisposition and environmental factors. There are many medicines for asthma management, the most important of which is corticosteroid. High doses of inhaled cor...

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Autores principales:	Alshaimaa Essam, Mohamed Abdel-Aal, Hesham Abd Al-samee
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	corticosteroids inhaled glucose asthma children Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/46f216e5f7b0456d8c3da5ee5be37c22
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spelling	oai:doaj.org-article:46f216e5f7b0456d8c3da5ee5be37c222021-12-02T13:52:45ZEffect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children2636-41742682-378010.21608/ijma.2020.22691.1083https://doaj.org/article/46f216e5f7b0456d8c3da5ee5be37c222020-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_94398_32d6ac199674491ef3be302aecd9a648.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Asthma is a common disease especially in kids. The development of asthma symptoms appears to involve a combination of genetic predisposition and environmental factors. There are many medicines for asthma management, the most important of which is corticosteroid. High doses of inhaled corticosteroids can be associated with hyperglycemia risk increase. Aim of the work: To detect the effect of inhaled corticosteroids on blood glucose homeostasis in asthmatic children. Patients and Methods:This study was conducted at pediatric inpatient and outpatient clinic of New Damietta Al-Azhar University Hospital in the period from September 2018 to September 2019, included 90 asthmatic children chosen randomly, 55 of them were males and 35 of them were females, aged from 2 to 12 years, For each child, the demographic data were collected, divided into three groups according to type of treatment, group I [using ICS only for more than 3 months], group II [using SCS] and group III [using ICS & SCS]. Results: Regarding WBCs and its differentiation there was a significant increase in WBCs [7.8±2.1] and eosinophil [2.7±0.83] in [group III] more than [group I]; WBCs [5.8±2.2] and eosinophil [1.4±0.6] and [group II]; WBCs [6.4±2.0] and eosinophil [1.5±0.7]. Regarding blood glucose, [group I] mean value was [89.6±22.8]; [group II] was [91.6±17.3]; [group III] was [104.4±36.1]. There was statistically significant difference between group I with III and group II with III [P2: 0.032 and P3: 0.043]. Conclusion: Blood glucose level increased in children using both inhaled and systemic corticosteroids and it was significant statistically.Alshaimaa EssamMohamed Abdel-AalHesham Abd Al-sameeAl-Azhar University, Faculty of Medicine (Damietta)articlecorticosteroidsinhaledglucoseasthmachildrenMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 3, Pp 645-649 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	corticosteroids inhaled glucose asthma children Medicine (General) R5-920
spellingShingle	corticosteroids inhaled glucose asthma children Medicine (General) R5-920 Alshaimaa Essam Mohamed Abdel-Aal Hesham Abd Al-samee Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children
description	Background: Asthma is a common disease especially in kids. The development of asthma symptoms appears to involve a combination of genetic predisposition and environmental factors. There are many medicines for asthma management, the most important of which is corticosteroid. High doses of inhaled corticosteroids can be associated with hyperglycemia risk increase. Aim of the work: To detect the effect of inhaled corticosteroids on blood glucose homeostasis in asthmatic children. Patients and Methods:This study was conducted at pediatric inpatient and outpatient clinic of New Damietta Al-Azhar University Hospital in the period from September 2018 to September 2019, included 90 asthmatic children chosen randomly, 55 of them were males and 35 of them were females, aged from 2 to 12 years, For each child, the demographic data were collected, divided into three groups according to type of treatment, group I [using ICS only for more than 3 months], group II [using SCS] and group III [using ICS & SCS]. Results: Regarding WBCs and its differentiation there was a significant increase in WBCs [7.8±2.1] and eosinophil [2.7±0.83] in [group III] more than [group I]; WBCs [5.8±2.2] and eosinophil [1.4±0.6] and [group II]; WBCs [6.4±2.0] and eosinophil [1.5±0.7]. Regarding blood glucose, [group I] mean value was [89.6±22.8]; [group II] was [91.6±17.3]; [group III] was [104.4±36.1]. There was statistically significant difference between group I with III and group II with III [P2: 0.032 and P3: 0.043]. Conclusion: Blood glucose level increased in children using both inhaled and systemic corticosteroids and it was significant statistically.
format	article
author	Alshaimaa Essam Mohamed Abdel-Aal Hesham Abd Al-samee
author_facet	Alshaimaa Essam Mohamed Abdel-Aal Hesham Abd Al-samee
author_sort	Alshaimaa Essam
title	Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children
title_short	Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children
title_full	Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children
title_fullStr	Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children
title_full_unstemmed	Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children
title_sort	effect of inhaled corticosteroids on blood glucose homeostasis in asthmatic children
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/46f216e5f7b0456d8c3da5ee5be37c22
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Effect of Inhaled Corticosteroids on Blood Glucose Homeostasis in Asthmatic Children

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