Scale-integrated Network Hubs of the White Matter Structural Network

Abstract The ‘human connectome’ concept has been proposed to significantly increase our understanding of how functional brain states emerge from their underlying structural substrates. Especially, the network hub has been considered one of the most important topological properties to interpret a net...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hunki Kwon, Yong-Ho Choi, Sang Won Seo, Jong-Min Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46f7df950ebf403a88bda39d5e4add01
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46f7df950ebf403a88bda39d5e4add01
record_format	dspace
spelling	oai:doaj.org-article:46f7df950ebf403a88bda39d5e4add012021-12-02T15:05:28ZScale-integrated Network Hubs of the White Matter Structural Network10.1038/s41598-017-02342-72045-2322https://doaj.org/article/46f7df950ebf403a88bda39d5e4add012017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02342-7https://doaj.org/toc/2045-2322Abstract The ‘human connectome’ concept has been proposed to significantly increase our understanding of how functional brain states emerge from their underlying structural substrates. Especially, the network hub has been considered one of the most important topological properties to interpret a network as a complex system. However, previous structural brain connectome studies have reported network hub regions based on various nodal resolutions. We hypothesized that brain network hubs should be determined considering various nodal scales in a certain range. We tested our hypothesis using the hub strength determined by the mean of the “hubness” values over a range of nodal scales. Some regions of the precuneus, superior occipital gyrus, and superior parietal gyrus in a bilaterally symmetric fashion had a relatively higher level of hub strength than other regions. These regions had a tendency of increasing contributions to local efficiency than other regions. We proposed a methodological framework to detect network hubs considering various nodal scales in a certain range. This framework might provide a benefit in the detection of important brain regions in the network.Hunki KwonYong-Ho ChoiSang Won SeoJong-Min LeeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hunki Kwon Yong-Ho Choi Sang Won Seo Jong-Min Lee Scale-integrated Network Hubs of the White Matter Structural Network
description	Abstract The ‘human connectome’ concept has been proposed to significantly increase our understanding of how functional brain states emerge from their underlying structural substrates. Especially, the network hub has been considered one of the most important topological properties to interpret a network as a complex system. However, previous structural brain connectome studies have reported network hub regions based on various nodal resolutions. We hypothesized that brain network hubs should be determined considering various nodal scales in a certain range. We tested our hypothesis using the hub strength determined by the mean of the “hubness” values over a range of nodal scales. Some regions of the precuneus, superior occipital gyrus, and superior parietal gyrus in a bilaterally symmetric fashion had a relatively higher level of hub strength than other regions. These regions had a tendency of increasing contributions to local efficiency than other regions. We proposed a methodological framework to detect network hubs considering various nodal scales in a certain range. This framework might provide a benefit in the detection of important brain regions in the network.
format	article
author	Hunki Kwon Yong-Ho Choi Sang Won Seo Jong-Min Lee
author_facet	Hunki Kwon Yong-Ho Choi Sang Won Seo Jong-Min Lee
author_sort	Hunki Kwon
title	Scale-integrated Network Hubs of the White Matter Structural Network
title_short	Scale-integrated Network Hubs of the White Matter Structural Network
title_full	Scale-integrated Network Hubs of the White Matter Structural Network
title_fullStr	Scale-integrated Network Hubs of the White Matter Structural Network
title_full_unstemmed	Scale-integrated Network Hubs of the White Matter Structural Network
title_sort	scale-integrated network hubs of the white matter structural network
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/46f7df950ebf403a88bda39d5e4add01
work_keys_str_mv	AT hunkikwon scaleintegratednetworkhubsofthewhitematterstructuralnetwork AT yonghochoi scaleintegratednetworkhubsofthewhitematterstructuralnetwork AT sangwonseo scaleintegratednetworkhubsofthewhitematterstructuralnetwork AT jongminlee scaleintegratednetworkhubsofthewhitematterstructuralnetwork
_version_	1718388826635763712

Scale-integrated Network Hubs of the White Matter Structural Network

Ejemplares similares