Interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum

Abstract The aim of this study was to investigate the association between immunoglobulins and SCC as a factor in shaping the content of the immunostimulatory components of colostrum. Seventy-eight multiparous Polish Holstein–Friesian cows were selected for the experiment. Colostrum samples were coll...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kamila Puppel, Marcin Gołębiewski, Jan Slósarz, Grzegorz Grodkowski, Paweł Solarczyk, Piotr Kostusiak, Kinga Grodkowska, Marek Balcerak, Tomasz Sakowski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46f966231ca846eea73a5fd222e1e8ad
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46f966231ca846eea73a5fd222e1e8ad
record_format	dspace
spelling	oai:doaj.org-article:46f966231ca846eea73a5fd222e1e8ad2021-12-02T18:49:27ZInteraction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum10.1038/s41598-021-95283-12045-2322https://doaj.org/article/46f966231ca846eea73a5fd222e1e8ad2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95283-1https://doaj.org/toc/2045-2322Abstract The aim of this study was to investigate the association between immunoglobulins and SCC as a factor in shaping the content of the immunostimulatory components of colostrum. Seventy-eight multiparous Polish Holstein–Friesian cows were selected for the experiment. Colostrum samples were collected immediately after calving (up to a max. of 2 h). The cows were divided into groups according to the following levels: Immunoglobulins (IG class)—(IG1) over 50 g/L, (IG2) up to 50 g/L; SCC class—(SCC1) up to 400 000/ml, (SCC2) 400–800 000/ml, (SCC3) over 800 000/ml. Colostrum assigned to the IG1 SCC1 group had a statistically significant higher (p ≤ 0.01) concentration of both whey proteins and fatty acids compared to the IG1 SCC2 and SCC3 groups. The concentration of IgG, IgM, and IgA was shown to be higher in IG1 SCC1 than IG2 SCC3 by 226%, 149%, and 115%, respectively. The concentration of lactoferrin was shown to be higher in IG1 SCC1 than IG2 SCC3 by 149%. The determination of colostrum quality based on the concentration of immunoglobulins in the colostrum may not be sufficient because serum IgG concentrations at birth show a linear increase relative to colostrum SCC. A breakdown of colostrum into quality classes, taking into account the level of SCC, should therefore be introduced.Kamila PuppelMarcin GołębiewskiJan SlósarzGrzegorz GrodkowskiPaweł SolarczykPiotr KostusiakKinga GrodkowskaMarek BalcerakTomasz SakowskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kamila Puppel Marcin Gołębiewski Jan Slósarz Grzegorz Grodkowski Paweł Solarczyk Piotr Kostusiak Kinga Grodkowska Marek Balcerak Tomasz Sakowski Interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum
description	Abstract The aim of this study was to investigate the association between immunoglobulins and SCC as a factor in shaping the content of the immunostimulatory components of colostrum. Seventy-eight multiparous Polish Holstein–Friesian cows were selected for the experiment. Colostrum samples were collected immediately after calving (up to a max. of 2 h). The cows were divided into groups according to the following levels: Immunoglobulins (IG class)—(IG1) over 50 g/L, (IG2) up to 50 g/L; SCC class—(SCC1) up to 400 000/ml, (SCC2) 400–800 000/ml, (SCC3) over 800 000/ml. Colostrum assigned to the IG1 SCC1 group had a statistically significant higher (p ≤ 0.01) concentration of both whey proteins and fatty acids compared to the IG1 SCC2 and SCC3 groups. The concentration of IgG, IgM, and IgA was shown to be higher in IG1 SCC1 than IG2 SCC3 by 226%, 149%, and 115%, respectively. The concentration of lactoferrin was shown to be higher in IG1 SCC1 than IG2 SCC3 by 149%. The determination of colostrum quality based on the concentration of immunoglobulins in the colostrum may not be sufficient because serum IgG concentrations at birth show a linear increase relative to colostrum SCC. A breakdown of colostrum into quality classes, taking into account the level of SCC, should therefore be introduced.
format	article
author	Kamila Puppel Marcin Gołębiewski Jan Slósarz Grzegorz Grodkowski Paweł Solarczyk Piotr Kostusiak Kinga Grodkowska Marek Balcerak Tomasz Sakowski
author_facet	Kamila Puppel Marcin Gołębiewski Jan Slósarz Grzegorz Grodkowski Paweł Solarczyk Piotr Kostusiak Kinga Grodkowska Marek Balcerak Tomasz Sakowski
author_sort	Kamila Puppel
title	Interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum
title_short	Interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum
title_full	Interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum
title_fullStr	Interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum
title_full_unstemmed	Interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum
title_sort	interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/46f966231ca846eea73a5fd222e1e8ad
work_keys_str_mv	AT kamilapuppel interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum AT marcingołebiewski interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum AT janslosarz interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum AT grzegorzgrodkowski interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum AT pawełsolarczyk interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum AT piotrkostusiak interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum AT kingagrodkowska interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum AT marekbalcerak interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum AT tomaszsakowski interactionbetweenthelevelofimmunoglobulinsandnumberofsomaticcellsasafactorshapingtheimmunomodulatingpropertiesofcolostrum
_version_	1718377558024650752

Interaction between the level of immunoglobulins and number of somatic cells as a factor shaping the immunomodulating properties of colostrum

Ejemplares similares