Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4

Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4

Armadillo (ARM) family proteins can act as oncogenes or tumor suppressors. Here, the authors show that a new ARM protein (ARMC12) is upregulated in neuroblastoma, binds the PRC2 component RBBP4, and inhibits transcription of tumor suppressive genes.

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Autores principales: Dan Li, Huajie Song, Hong Mei, Erhu Fang, Xiaojing Wang, Feng Yang, Huanhuan Li, Yajun Chen, Kai Huang, Liduan Zheng, Qiangsong Tong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/46fa6a22480b40dc9cccd28b7a9bc751
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spelling oai:doaj.org-article:46fa6a22480b40dc9cccd28b7a9bc7512021-12-02T17:33:16ZArmadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 410.1038/s41467-018-05286-22041-1723https://doaj.org/article/46fa6a22480b40dc9cccd28b7a9bc7512018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05286-2https://doaj.org/toc/2041-1723Armadillo (ARM) family proteins can act as oncogenes or tumor suppressors. Here, the authors show that a new ARM protein (ARMC12) is upregulated in neuroblastoma, binds the PRC2 component RBBP4, and inhibits transcription of tumor suppressive genes.Dan LiHuajie SongHong MeiErhu FangXiaojing WangFeng YangHuanhuan LiYajun ChenKai HuangLiduan ZhengQiangsong TongNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Dan Li
Huajie Song
Hong Mei
Erhu Fang
Xiaojing Wang
Feng Yang
Huanhuan Li
Yajun Chen
Kai Huang
Liduan Zheng
Qiangsong Tong
Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4
description Armadillo (ARM) family proteins can act as oncogenes or tumor suppressors. Here, the authors show that a new ARM protein (ARMC12) is upregulated in neuroblastoma, binds the PRC2 component RBBP4, and inhibits transcription of tumor suppressive genes.
format article
author Dan Li
Huajie Song
Hong Mei
Erhu Fang
Xiaojing Wang
Feng Yang
Huanhuan Li
Yajun Chen
Kai Huang
Liduan Zheng
Qiangsong Tong
author_facet Dan Li
Huajie Song
Hong Mei
Erhu Fang
Xiaojing Wang
Feng Yang
Huanhuan Li
Yajun Chen
Kai Huang
Liduan Zheng
Qiangsong Tong
author_sort Dan Li
title Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4
title_short Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4
title_full Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4
title_fullStr Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4
title_full_unstemmed Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4
title_sort armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/46fa6a22480b40dc9cccd28b7a9bc751
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AT hongmei armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
AT erhufang armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
AT xiaojingwang armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
AT fengyang armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
AT huanhuanli armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
AT yajunchen armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
AT kaihuang armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
AT liduanzheng armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
AT qiangsongtong armadillorepeatcontaining12promotesneuroblastomaprogressionthroughinteractionwithretinoblastomabindingprotein4
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