Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program

Author summary TDP-43 aggregation is linked to various diseases including amyotrophic lateral sclerosis. Here the authors show that acetylation of the protein triggers TDP-43 pathology in cultured cells and mouse skeletal muscle, which can be cleared through an HSF1-dependent chaperone mechanism tha...

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Autores principales:	Ping Wang, Connor M. Wander, Chao-Xing Yuan, Michael S. Bereman, Todd J. Cohen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46fad8dc2b444576bc81981652f2f6f9
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spelling	oai:doaj.org-article:46fad8dc2b444576bc81981652f2f6f92021-12-02T13:57:44ZAcetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program10.1038/s41467-017-00088-42041-1723https://doaj.org/article/46fad8dc2b444576bc81981652f2f6f92017-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00088-4https://doaj.org/toc/2041-1723Author summary TDP-43 aggregation is linked to various diseases including amyotrophic lateral sclerosis. Here the authors show that acetylation of the protein triggers TDP-43 pathology in cultured cells and mouse skeletal muscle, which can be cleared through an HSF1-dependent chaperone mechanism that disaggregates the protein.Ping WangConnor M. WanderChao-Xing YuanMichael S. BeremanTodd J. CohenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ping Wang Connor M. Wander Chao-Xing Yuan Michael S. Bereman Todd J. Cohen Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
description	Author summary TDP-43 aggregation is linked to various diseases including amyotrophic lateral sclerosis. Here the authors show that acetylation of the protein triggers TDP-43 pathology in cultured cells and mouse skeletal muscle, which can be cleared through an HSF1-dependent chaperone mechanism that disaggregates the protein.
format	article
author	Ping Wang Connor M. Wander Chao-Xing Yuan Michael S. Bereman Todd J. Cohen
author_facet	Ping Wang Connor M. Wander Chao-Xing Yuan Michael S. Bereman Todd J. Cohen
author_sort	Ping Wang
title	Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
title_short	Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
title_full	Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
title_fullStr	Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
title_full_unstemmed	Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program
title_sort	acetylation-induced tdp-43 pathology is suppressed by an hsf1-dependent chaperone program
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/46fad8dc2b444576bc81981652f2f6f9
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Acetylation-induced TDP-43 pathology is suppressed by an HSF1-dependent chaperone program

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