Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma

Tarek A Shazly1,2, Jan Smith3, Mark A Latina41Ophthalmology Department, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; 2Ophthalmology, Assiut University Hospital, Assiut, Egypt; 3Oslo Eye Institute, Oslo, Norway; 4Reading Health Center, Reading, MA, USAPurpose: To inve...

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Autores principales:	Tarek A Shazly, Jan Smith, Mark A Latina
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/46fb13389e1d4b228c4e1bbe86193a6b
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spelling	oai:doaj.org-article:46fb13389e1d4b228c4e1bbe86193a6b2021-12-02T07:38:28ZLong-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma1177-54671177-5483https://doaj.org/article/46fb13389e1d4b228c4e1bbe86193a6b2010-12-01T00:00:00Zhttp://www.dovepress.com/long-term-safety-and-efficacy-of-selective-laser-trabeculoplasty-as-pr-a5918https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Tarek A Shazly1,2, Jan Smith3, Mark A Latina41Ophthalmology Department, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; 2Ophthalmology, Assiut University Hospital, Assiut, Egypt; 3Oslo Eye Institute, Oslo, Norway; 4Reading Health Center, Reading, MA, USAPurpose: To investigate the safety and efficacy of selective laser trabeculoplasty (SLT) to reduce intraocular pressure (IOP) in patients with pseudoexfoliation glaucoma (PXFG) compared with primary open-angle glaucoma (POAG).Design: Non-randomized, prospective, clinical trial.Methods: Nineteen eyes of 13 patients with POAG and 18 eyes of 13 patients with PXFG were treated with SLT. Patients were followed without antiglaucoma medications until additional medical, laser, or surgical intervention was initiated, at which time they were considered failures, had withdrawn from the study, or underwent a second SLT.Results: The POAG and PXFG eyes showed similar reductions of IOP over the 49 months of follow-up. At 30 months of follow-up the POAG group showed a mean IOP of 17.6 &plusmn; 2.8 mmHg and a mean IOP reduction of 5.7 &plusmn; 2.1 mmHg; the PXFG group showed a mean IOP of 18.3 &plusmn; 4.7 and a mean IOP reduction of 5.3 &plusmn; 3.0 mmHg. Four eyes in the PXFG group and three eyes in the POAG group failed by 30 months. The cumulative probability of success was 74% for the PXFG group and 77% for the POAG group. Four PXFG eyes underwent a second SLT after 30 months of follow-up with a final IOP of 17.6 &plusmn; 2.8 mmHg. There were no serious adverse events.Conclusion: SLT is a safe and effective method to lower IOP in patients with PXFG as initial glaucoma therapy. Both groups showed similar IOP reductions and failure rates.Keywords: glaucoma, selective laser trabeculoplasty, primary open angle glaucoma, pseudoexfoliation glaucoma, intraocular pressure, laser, trabecular meshwork Tarek A ShazlyJan SmithMark A LatinaDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 5-10 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Tarek A Shazly Jan Smith Mark A Latina Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma
description	Tarek A Shazly1,2, Jan Smith3, Mark A Latina41Ophthalmology Department, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; 2Ophthalmology, Assiut University Hospital, Assiut, Egypt; 3Oslo Eye Institute, Oslo, Norway; 4Reading Health Center, Reading, MA, USAPurpose: To investigate the safety and efficacy of selective laser trabeculoplasty (SLT) to reduce intraocular pressure (IOP) in patients with pseudoexfoliation glaucoma (PXFG) compared with primary open-angle glaucoma (POAG).Design: Non-randomized, prospective, clinical trial.Methods: Nineteen eyes of 13 patients with POAG and 18 eyes of 13 patients with PXFG were treated with SLT. Patients were followed without antiglaucoma medications until additional medical, laser, or surgical intervention was initiated, at which time they were considered failures, had withdrawn from the study, or underwent a second SLT.Results: The POAG and PXFG eyes showed similar reductions of IOP over the 49 months of follow-up. At 30 months of follow-up the POAG group showed a mean IOP of 17.6 &plusmn; 2.8 mmHg and a mean IOP reduction of 5.7 &plusmn; 2.1 mmHg; the PXFG group showed a mean IOP of 18.3 &plusmn; 4.7 and a mean IOP reduction of 5.3 &plusmn; 3.0 mmHg. Four eyes in the PXFG group and three eyes in the POAG group failed by 30 months. The cumulative probability of success was 74% for the PXFG group and 77% for the POAG group. Four PXFG eyes underwent a second SLT after 30 months of follow-up with a final IOP of 17.6 &plusmn; 2.8 mmHg. There were no serious adverse events.Conclusion: SLT is a safe and effective method to lower IOP in patients with PXFG as initial glaucoma therapy. Both groups showed similar IOP reductions and failure rates.Keywords: glaucoma, selective laser trabeculoplasty, primary open angle glaucoma, pseudoexfoliation glaucoma, intraocular pressure, laser, trabecular meshwork
format	article
author	Tarek A Shazly Jan Smith Mark A Latina
author_facet	Tarek A Shazly Jan Smith Mark A Latina
author_sort	Tarek A Shazly
title	Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma
title_short	Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma
title_full	Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma
title_fullStr	Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma
title_full_unstemmed	Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma
title_sort	long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/46fb13389e1d4b228c4e1bbe86193a6b
work_keys_str_mv	AT tarekashazly longtermsafetyandefficacyofselectivelasertrabeculoplastyasprimarytherapyforthetreatmentofpseudoexfoliationglaucomacomparedwithprimaryopenangleglaucoma AT jansmith longtermsafetyandefficacyofselectivelasertrabeculoplastyasprimarytherapyforthetreatmentofpseudoexfoliationglaucomacomparedwithprimaryopenangleglaucoma AT markalatina longtermsafetyandefficacyofselectivelasertrabeculoplastyasprimarytherapyforthetreatmentofpseudoexfoliationglaucomacomparedwithprimaryopenangleglaucoma
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Long-term safety and efficacy of selective laser trabeculoplasty as primary therapy for the treatment of pseudoexfoliation glaucoma compared with primary open-angle glaucoma

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