S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen

Vibrio parahaemolyticus causes seafood-borne diarrheal diseases. Here, the authors show that the pathogen uses a histidine kinase to sense host-derived nitrite and downregulate a proinflammatory type 3 secretion system, thus enhancing intestinal colonization and virulence.

Guardado en:

Detalles Bibliográficos
Autores principales:	Dan Gu, Yibei Zhang, Qiyao Wang, Xiaohui Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/46fcb59b1af74d2e9601658000d87e2c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:46fcb59b1af74d2e9601658000d87e2c
record_format	dspace
spelling	oai:doaj.org-article:46fcb59b1af74d2e9601658000d87e2c2021-12-02T16:56:35ZS-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen10.1038/s41467-020-19506-12041-1723https://doaj.org/article/46fcb59b1af74d2e9601658000d87e2c2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19506-1https://doaj.org/toc/2041-1723Vibrio parahaemolyticus causes seafood-borne diarrheal diseases. Here, the authors show that the pathogen uses a histidine kinase to sense host-derived nitrite and downregulate a proinflammatory type 3 secretion system, thus enhancing intestinal colonization and virulence.Dan GuYibei ZhangQiyao WangXiaohui ZhouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dan Gu Yibei Zhang Qiyao Wang Xiaohui Zhou S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen
description	Vibrio parahaemolyticus causes seafood-borne diarrheal diseases. Here, the authors show that the pathogen uses a histidine kinase to sense host-derived nitrite and downregulate a proinflammatory type 3 secretion system, thus enhancing intestinal colonization and virulence.
format	article
author	Dan Gu Yibei Zhang Qiyao Wang Xiaohui Zhou
author_facet	Dan Gu Yibei Zhang Qiyao Wang Xiaohui Zhou
author_sort	Dan Gu
title	S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen
title_short	S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen
title_full	S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen
title_fullStr	S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen
title_full_unstemmed	S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen
title_sort	s-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/46fcb59b1af74d2e9601658000d87e2c
work_keys_str_mv	AT dangu snitrosylationmediatedactivationofahistidinekinaserepressesthetype3secretionsystemandpromotesvirulenceofanentericpathogen AT yibeizhang snitrosylationmediatedactivationofahistidinekinaserepressesthetype3secretionsystemandpromotesvirulenceofanentericpathogen AT qiyaowang snitrosylationmediatedactivationofahistidinekinaserepressesthetype3secretionsystemandpromotesvirulenceofanentericpathogen AT xiaohuizhou snitrosylationmediatedactivationofahistidinekinaserepressesthetype3secretionsystemandpromotesvirulenceofanentericpathogen
_version_	1718382796935790592

S-nitrosylation-mediated activation of a histidine kinase represses the type 3 secretion system and promotes virulence of an enteric pathogen

Ejemplares similares