Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy

Decoding topologically associating domains with ultra-low resolution Hi-C data by graph structural entropy

Accurate detection of TADs requires ultra-deep sequencing and sophisticated normalisation procedures, which limits the analysis of Hi-C data. Here the authors develop a normalisation-free method to decode the domains of chromosomes (deDoc) that utilizes structural entropy to predict TADs with ultra-...

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Autores principales: Angsheng Li, Xianchen Yin, Bingxiang Xu, Danyang Wang, Jimin Han, Yi Wei, Yun Deng, Ying Xiong, Zhihua Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/46fdb2762a7445d7993295e078768865
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