Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.

<h4>Background</h4>Previous studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal glucose tolerance but not patients with type 2 diabetes. There are limited data available concerning fetuin-A and insulin resistance in Chinese. We aimed to stu...

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Autores principales:	Aiyun Song, Min Xu, Yufang Bi, Yu Xu, Yun Huang, Mian Li, Tiange Wang, Yaohua Wu, Yu Liu, Xiaoying Li, Yuhong Chen, Weiqing Wang, Guang Ning
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/46feeb1f6929447eb17eec9449cc3445
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spelling	oai:doaj.org-article:46feeb1f6929447eb17eec9449cc34452021-11-18T06:55:04ZSerum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.1932-620310.1371/journal.pone.0019228https://doaj.org/article/46feeb1f6929447eb17eec9449cc34452011-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21556362/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Previous studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal glucose tolerance but not patients with type 2 diabetes. There are limited data available concerning fetuin-A and insulin resistance in Chinese. We aimed to study the association of fetuin-A with insulin resistance among participants with or without type 2 diabetes in a large sample size of adults aged 40 and older.<h4>Methodology and principal findings</h4>A community-based cross-sectional study was performed among 5,227 Chinese adults. The average age of our study was 61.5±9.9 years. Serum fetuin-A concentrations were not significantly different between male and female (296.9 vs. 292.9 mg/l, p = 0.11). Compared with the lowest quartile, the highest quartile of serum fetuin-A revealed a significant higher proportion of type 2 diabetic patients (34.8% vs. 27.3%, p<0.0001). In the multinomial logit models, the risk of type 2 diabetes was associated with each one quartile increase of serum fetuin-A concentrations when referenced not only to normal glucose tolerance (OR 1.24, 95% CI 1.07-1.43, p = 0.004) but also to impaired glucose regulation (OR 1.25, 95% CI 1.08-1.44, p = 0.003, respectively), after adjustment for age, sex, community, current smoking, and current drinking. The logistic regression analysis showed that fetuin-A were associated with elevated HOMA-IR and fasting serum insulin both among the participants with or without type 2 diabetes in the full adjusted analysis. There was no significant association between elevated serum fetuin-A concentrations and impaired glucose regulation (all p≥0.12).<h4>Conclusions and significance</h4>Higher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance in middle aged and elderly Chinese.Aiyun SongMin XuYufang BiYu XuYun HuangMian LiTiange WangYaohua WuYu LiuXiaoying LiYuhong ChenWeiqing WangGuang NingPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 4, p e19228 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aiyun Song Min Xu Yufang Bi Yu Xu Yun Huang Mian Li Tiange Wang Yaohua Wu Yu Liu Xiaoying Li Yuhong Chen Weiqing Wang Guang Ning Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.
description	<h4>Background</h4>Previous studies have demonstrated that fetuin-A is related to insulin resistance among subjects with normal glucose tolerance but not patients with type 2 diabetes. There are limited data available concerning fetuin-A and insulin resistance in Chinese. We aimed to study the association of fetuin-A with insulin resistance among participants with or without type 2 diabetes in a large sample size of adults aged 40 and older.<h4>Methodology and principal findings</h4>A community-based cross-sectional study was performed among 5,227 Chinese adults. The average age of our study was 61.5±9.9 years. Serum fetuin-A concentrations were not significantly different between male and female (296.9 vs. 292.9 mg/l, p = 0.11). Compared with the lowest quartile, the highest quartile of serum fetuin-A revealed a significant higher proportion of type 2 diabetic patients (34.8% vs. 27.3%, p<0.0001). In the multinomial logit models, the risk of type 2 diabetes was associated with each one quartile increase of serum fetuin-A concentrations when referenced not only to normal glucose tolerance (OR 1.24, 95% CI 1.07-1.43, p = 0.004) but also to impaired glucose regulation (OR 1.25, 95% CI 1.08-1.44, p = 0.003, respectively), after adjustment for age, sex, community, current smoking, and current drinking. The logistic regression analysis showed that fetuin-A were associated with elevated HOMA-IR and fasting serum insulin both among the participants with or without type 2 diabetes in the full adjusted analysis. There was no significant association between elevated serum fetuin-A concentrations and impaired glucose regulation (all p≥0.12).<h4>Conclusions and significance</h4>Higher fetuin-A concentrations were associated with type 2 diabetes and insulin resistance in middle aged and elderly Chinese.
format	article
author	Aiyun Song Min Xu Yufang Bi Yu Xu Yun Huang Mian Li Tiange Wang Yaohua Wu Yu Liu Xiaoying Li Yuhong Chen Weiqing Wang Guang Ning
author_facet	Aiyun Song Min Xu Yufang Bi Yu Xu Yun Huang Mian Li Tiange Wang Yaohua Wu Yu Liu Xiaoying Li Yuhong Chen Weiqing Wang Guang Ning
author_sort	Aiyun Song
title	Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.
title_short	Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.
title_full	Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.
title_fullStr	Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.
title_full_unstemmed	Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.
title_sort	serum fetuin-a associates with type 2 diabetes and insulin resistance in chinese adults.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/46feeb1f6929447eb17eec9449cc3445
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Serum fetuin-A associates with type 2 diabetes and insulin resistance in Chinese adults.

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