Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses

Cholinergic neurons in the diagonal band of Broca degenerate early in Alzheimer’s disease. Here the authors show that in healthy mice, these cholinergic inputs innervate newborn neurons in the hippocampus, and that loss of this innervation in an Alzheimer’s disease model leads to impairments in spat...

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Autores principales:	Houze Zhu, Huanhuan Yan, Na Tang, Xinyan Li, Pei Pang, Hao Li, Wenting Chen, Yu Guo, Shu Shu, You Cai, Lei Pei, Dan Liu, Min-Hua Luo, Hengye Man, Qing Tian, Yangling Mu, Ling-Qiang Zhu, Youming Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/4700eda4343f4ed69de872b644ee5744
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spelling	oai:doaj.org-article:4700eda4343f4ed69de872b644ee57442021-12-02T14:40:23ZImpairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses10.1038/s41467-017-01943-02041-1723https://doaj.org/article/4700eda4343f4ed69de872b644ee57442017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01943-0https://doaj.org/toc/2041-1723Cholinergic neurons in the diagonal band of Broca degenerate early in Alzheimer’s disease. Here the authors show that in healthy mice, these cholinergic inputs innervate newborn neurons in the hippocampus, and that loss of this innervation in an Alzheimer’s disease model leads to impairments in spatial memory.Houze ZhuHuanhuan YanNa TangXinyan LiPei PangHao LiWenting ChenYu GuoShu ShuYou CaiLei PeiDan LiuMin-Hua LuoHengye ManQing TianYangling MuLing-Qiang ZhuYouming LuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Houze Zhu Huanhuan Yan Na Tang Xinyan Li Pei Pang Hao Li Wenting Chen Yu Guo Shu Shu You Cai Lei Pei Dan Liu Min-Hua Luo Hengye Man Qing Tian Yangling Mu Ling-Qiang Zhu Youming Lu Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
description	Cholinergic neurons in the diagonal band of Broca degenerate early in Alzheimer’s disease. Here the authors show that in healthy mice, these cholinergic inputs innervate newborn neurons in the hippocampus, and that loss of this innervation in an Alzheimer’s disease model leads to impairments in spatial memory.
format	article
author	Houze Zhu Huanhuan Yan Na Tang Xinyan Li Pei Pang Hao Li Wenting Chen Yu Guo Shu Shu You Cai Lei Pei Dan Liu Min-Hua Luo Hengye Man Qing Tian Yangling Mu Ling-Qiang Zhu Youming Lu
author_facet	Houze Zhu Huanhuan Yan Na Tang Xinyan Li Pei Pang Hao Li Wenting Chen Yu Guo Shu Shu You Cai Lei Pei Dan Liu Min-Hua Luo Hengye Man Qing Tian Yangling Mu Ling-Qiang Zhu Youming Lu
author_sort	Houze Zhu
title	Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
title_short	Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
title_full	Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
title_fullStr	Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
title_full_unstemmed	Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
title_sort	impairments of spatial memory in an alzheimer’s disease model via degeneration of hippocampal cholinergic synapses
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/4700eda4343f4ed69de872b644ee5744
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Impairments of spatial memory in an Alzheimer’s disease model via degeneration of hippocampal cholinergic synapses

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