Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes

Single-cell CAS-seq reveals a class of short PIWI-interacting RNAs in human oocytes

PIWI-interacting RNAs (piRNAs) are ~25–33 nt small RNAs expressed in animal germ cells. Here, the authors develop a single-cell small RNA sequencing method and report that a class of ~20-nt piRNAs lacking 3′ end 2′-O-methylation are associated with PIWIL3 protein and predominantly expressed in human...

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Detalles Bibliográficos
Autores principales: Qiyuan Yang, Ronghong Li, Qifeng Lyu, Li Hou, Zhen Liu, Qiang Sun, Miao Liu, Huijuan Shi, Beiying Xu, Mingru Yin, Zhiguang Yan, Ying Huang, Mofang Liu, Yiping Li, Ligang Wu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/47021d58304e4f73bb96867ba072e9cd
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Sumario:PIWI-interacting RNAs (piRNAs) are ~25–33 nt small RNAs expressed in animal germ cells. Here, the authors develop a single-cell small RNA sequencing method and report that a class of ~20-nt piRNAs lacking 3′ end 2′-O-methylation are associated with PIWIL3 protein and predominantly expressed in human and monkey oocytes.

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