K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins

K336I mutant actin alters the structure of neighbouring protomers in filaments and reduces affinity for actin-binding proteins

Abstract Mutation of the Lys-336 residue of actin to Ile (K336I) or Asp (K336E) causes congenital myopathy. To understand the effect of this mutation on the function of actin filaments and gain insight into the mechanism of disease onset, we prepared and biochemically characterised K336I mutant acti...

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Autores principales: Nobuhisa Umeki, Keitaro Shibata, Taro Q. P. Noguchi, Keiko Hirose, Yasushi Sako, Taro Q. P. Uyeda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/47043d6050ef477ba9bafdcf76f063b1
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