The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter
The serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for the allosteric site.
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Nature Portfolio
2020
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oai:doaj.org-article:4706c23f56b542ffad3d502b3f12fe7e2021-12-02T14:42:46ZThe mechanism of a high-affinity allosteric inhibitor of the serotonin transporter10.1038/s41467-020-15292-y2041-1723https://doaj.org/article/4706c23f56b542ffad3d502b3f12fe7e2020-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15292-yhttps://doaj.org/toc/2041-1723The serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for the allosteric site.Per PlengeAra M. AbramyanGunnar SørensenArne MørkPia WeikopUlrik GetherBenny Bang-AndersenLei ShiClaus J. LolandNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Per Plenge Ara M. Abramyan Gunnar Sørensen Arne Mørk Pia Weikop Ulrik Gether Benny Bang-Andersen Lei Shi Claus J. Loland The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter |
| description |
The serotonin transporter (SERT) terminates serotonin signaling and its activity is modulated by antidepressants. Here authors reveal the mechanistic details underlying the coupling between the two binding sites in SERT and a high-affinity ligand for the allosteric site. |
| format |
article |
| author |
Per Plenge Ara M. Abramyan Gunnar Sørensen Arne Mørk Pia Weikop Ulrik Gether Benny Bang-Andersen Lei Shi Claus J. Loland |
| author_facet |
Per Plenge Ara M. Abramyan Gunnar Sørensen Arne Mørk Pia Weikop Ulrik Gether Benny Bang-Andersen Lei Shi Claus J. Loland |
| author_sort |
Per Plenge |
| title |
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter |
| title_short |
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter |
| title_full |
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter |
| title_fullStr |
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter |
| title_full_unstemmed |
The mechanism of a high-affinity allosteric inhibitor of the serotonin transporter |
| title_sort |
mechanism of a high-affinity allosteric inhibitor of the serotonin transporter |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/4706c23f56b542ffad3d502b3f12fe7e |
| work_keys_str_mv |
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1718389564094021632 |