Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen

The article expands our knowledge on the variety of biodegraders of ibuprofen, one of the most frequently detected non-steroidal anti-inflammatory drugs in the environment. We studied the dynamics of ibuprofen decomposition and its relationship with the physiological status of bacteria and with addi...

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Auteurs principaux:	Irina B. Ivshina, Elena A. Tyumina, Grigory A. Bazhutin, Elena V. Vikhareva
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2021
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/47079ff8263b4ba8b4f45b791eab2256
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spelling	oai:doaj.org-article:47079ff8263b4ba8b4f45b791eab22562021-11-25T06:19:34ZResponse of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen1932-6203https://doaj.org/article/47079ff8263b4ba8b4f45b791eab22562021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8601567/?tool=EBIhttps://doaj.org/toc/1932-6203The article expands our knowledge on the variety of biodegraders of ibuprofen, one of the most frequently detected non-steroidal anti-inflammatory drugs in the environment. We studied the dynamics of ibuprofen decomposition and its relationship with the physiological status of bacteria and with additional carbon and energy sources. The involvement of cytoplasmic enzymes in ibuprofen biodegradation was confirmed. Within the tested actinobacteria, Rhodococcus cerastii IEGM 1278 was capable of complete oxidation of 100 μg/L and 100 mg/L of ibuprofen in 30 h and 144 h, respectively, in the presence of an alternative carbon source (n-hexadecane). Besides, the presence of ibuprofen induced a transition of rhodococci from single- to multicellular lifeforms, a shift to more negative zeta potential values, and a decrease in the membrane permeability. The initial steps of ibuprofen biotransformation by R. cerastii IEGM 1278 involved the formation of hydroxylated and decarboxylated derivatives with higher phytotoxicity than the parent compound (ibuprofen). The data obtained indicate potential threats of this pharmaceutical pollutant and its metabolites to biota and natural ecosystems.Irina B. IvshinaElena A. TyuminaGrigory A. BazhutinElena V. VikharevaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Irina B. Ivshina Elena A. Tyumina Grigory A. Bazhutin Elena V. Vikhareva Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen
description	The article expands our knowledge on the variety of biodegraders of ibuprofen, one of the most frequently detected non-steroidal anti-inflammatory drugs in the environment. We studied the dynamics of ibuprofen decomposition and its relationship with the physiological status of bacteria and with additional carbon and energy sources. The involvement of cytoplasmic enzymes in ibuprofen biodegradation was confirmed. Within the tested actinobacteria, Rhodococcus cerastii IEGM 1278 was capable of complete oxidation of 100 μg/L and 100 mg/L of ibuprofen in 30 h and 144 h, respectively, in the presence of an alternative carbon source (n-hexadecane). Besides, the presence of ibuprofen induced a transition of rhodococci from single- to multicellular lifeforms, a shift to more negative zeta potential values, and a decrease in the membrane permeability. The initial steps of ibuprofen biotransformation by R. cerastii IEGM 1278 involved the formation of hydroxylated and decarboxylated derivatives with higher phytotoxicity than the parent compound (ibuprofen). The data obtained indicate potential threats of this pharmaceutical pollutant and its metabolites to biota and natural ecosystems.
format	article
author	Irina B. Ivshina Elena A. Tyumina Grigory A. Bazhutin Elena V. Vikhareva
author_facet	Irina B. Ivshina Elena A. Tyumina Grigory A. Bazhutin Elena V. Vikhareva
author_sort	Irina B. Ivshina
title	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen
title_short	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen
title_full	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen
title_fullStr	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen
title_full_unstemmed	Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen
title_sort	response of rhodococcus cerastii iegm 1278 to toxic effects of ibuprofen
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/47079ff8263b4ba8b4f45b791eab2256
work_keys_str_mv	AT irinabivshina responseofrhodococcuscerastiiiegm1278totoxiceffectsofibuprofen AT elenaatyumina responseofrhodococcuscerastiiiegm1278totoxiceffectsofibuprofen AT grigoryabazhutin responseofrhodococcuscerastiiiegm1278totoxiceffectsofibuprofen AT elenavvikhareva responseofrhodococcuscerastiiiegm1278totoxiceffectsofibuprofen
_version_	1718413860319264768

Response of Rhodococcus cerastii IEGM 1278 to toxic effects of ibuprofen

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