Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles

Takanori Kanazawa School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan Abstract: Recently, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. In this review, we...

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Autor principal:	Kanazawa T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/470a82d69d104f53adfd238dfa241025
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spelling	oai:doaj.org-article:470a82d69d104f53adfd238dfa2410252021-12-02T01:41:43ZBrain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles1179-1470https://doaj.org/article/470a82d69d104f53adfd238dfa2410252015-01-01T00:00:00Zhttp://www.dovepress.com/brain-delivery-of-small-interfering-ribonucleic-acid-and-drugs-through-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470 Takanori Kanazawa School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan Abstract: Recently, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. In this review, we summarize our studies evaluating nose-to-brain delivery of drugs and small interfering ribonucleic acids in combination with cell-penetrating peptide-modified polymer micelles. Our findings show that the use of polymer micelles with surface modification with Tat peptide in the intranasal administration enables the non-invasive delivery of therapeutic agents to the brain by increasing the transfer of the administered drug or small interfering ribonucleic acid to the central nervous system from the nasal cavity. Keywords: nose-to-brain, polymer micelles, cell-penetrating peptide, intranasal administration, nucleic acidKanazawa TDove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2015, Iss default, Pp 57-64 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Kanazawa T Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles
description	Takanori Kanazawa School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan Abstract: Recently, the development of effective strategies for enhancing drug delivery to the brain has been a topic of great interest in both clinical and pharmaceutical fields. In this review, we summarize our studies evaluating nose-to-brain delivery of drugs and small interfering ribonucleic acids in combination with cell-penetrating peptide-modified polymer micelles. Our findings show that the use of polymer micelles with surface modification with Tat peptide in the intranasal administration enables the non-invasive delivery of therapeutic agents to the brain by increasing the transfer of the administered drug or small interfering ribonucleic acid to the central nervous system from the nasal cavity. Keywords: nose-to-brain, polymer micelles, cell-penetrating peptide, intranasal administration, nucleic acid
format	article
author	Kanazawa T
author_facet	Kanazawa T
author_sort	Kanazawa T
title	Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles
title_short	Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles
title_full	Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles
title_fullStr	Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles
title_full_unstemmed	Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles
title_sort	brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/470a82d69d104f53adfd238dfa241025
work_keys_str_mv	AT kanazawat braindeliveryofsmallinterferingribonucleicacidanddrugsthroughintranasaladministrationwithnanosizedpolymermicelles
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Brain delivery of small interfering ribonucleic acid and drugs through intranasal administration with nano-sized polymer micelles

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