Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma

Abstract Here, we present two patients with bronchial asthma, who developed keratosis pilaris (KP) following treatment with dupilumab, a monoclonal antibody to IL‐4 receptor. Both of them reported pruritic papules in their extremities in 1 months after initiation of dupilumab therapy. The lesions ne...

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Autores principales:	Yuka Shibata, Shigetoshi Sano
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	bronchial asthma curly hair dupilumab hair follicle keratosis pilaris Th2 pathway Dermatology RL1-803 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/4710040ae2894f3f9200982a22409a58
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spelling	oai:doaj.org-article:4710040ae2894f3f9200982a22409a582021-11-10T05:50:44ZKeratosis pilaris caused by dupilumab for the treatment of bronchial asthma2574-459310.1002/cia2.12172https://doaj.org/article/4710040ae2894f3f9200982a22409a582021-08-01T00:00:00Zhttps://doi.org/10.1002/cia2.12172https://doaj.org/toc/2574-4593Abstract Here, we present two patients with bronchial asthma, who developed keratosis pilaris (KP) following treatment with dupilumab, a monoclonal antibody to IL‐4 receptor. Both of them reported pruritic papules in their extremities in 1 months after initiation of dupilumab therapy. The lesions newly developed on the day of every administration of dupilumab at 2‐week interval, however, they tended to resolve over time until the next treatment. A diagnosis of KP was made from clinical and histopathologic findings. Dermoscopic examination revealed keratotic plugs with coiled, curly hairs. We suspected that dupilumab might abruptly impact on growth of vellus hair to generate KP.Yuka ShibataShigetoshi SanoWileyarticlebronchial asthmacurly hairdupilumabhair folliclekeratosis pilarisTh2 pathwayDermatologyRL1-803Immunologic diseases. AllergyRC581-607ENJournal of Cutaneous Immunology and Allergy, Vol 4, Iss 4, Pp 82-85 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bronchial asthma curly hair dupilumab hair follicle keratosis pilaris Th2 pathway Dermatology RL1-803 Immunologic diseases. Allergy RC581-607
spellingShingle	bronchial asthma curly hair dupilumab hair follicle keratosis pilaris Th2 pathway Dermatology RL1-803 Immunologic diseases. Allergy RC581-607 Yuka Shibata Shigetoshi Sano Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma
description	Abstract Here, we present two patients with bronchial asthma, who developed keratosis pilaris (KP) following treatment with dupilumab, a monoclonal antibody to IL‐4 receptor. Both of them reported pruritic papules in their extremities in 1 months after initiation of dupilumab therapy. The lesions newly developed on the day of every administration of dupilumab at 2‐week interval, however, they tended to resolve over time until the next treatment. A diagnosis of KP was made from clinical and histopathologic findings. Dermoscopic examination revealed keratotic plugs with coiled, curly hairs. We suspected that dupilumab might abruptly impact on growth of vellus hair to generate KP.
format	article
author	Yuka Shibata Shigetoshi Sano
author_facet	Yuka Shibata Shigetoshi Sano
author_sort	Yuka Shibata
title	Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma
title_short	Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma
title_full	Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma
title_fullStr	Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma
title_full_unstemmed	Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma
title_sort	keratosis pilaris caused by dupilumab for the treatment of bronchial asthma
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/4710040ae2894f3f9200982a22409a58
work_keys_str_mv	AT yukashibata keratosispilariscausedbydupilumabforthetreatmentofbronchialasthma AT shigetoshisano keratosispilariscausedbydupilumabforthetreatmentofbronchialasthma
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Keratosis pilaris caused by dupilumab for the treatment of bronchial asthma

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