Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation

Inflammation contributes to the development of metabolic disease through incompletely understood mechanisms. Here the authors report that deletion of the transcription factor KLF2 in myeloid cells leads to increased feeding and weight gain in mice with concomitant peripheral and central tissue infla...

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Autores principales:	David R. Sweet, Neelakantan T. Vasudevan, Liyan Fan, Chloe E. Booth, Komal S. Keerthy, Xudong Liao, Vinesh Vinayachandran, Yoichi Takami, Derin Tugal, Nikunj Sharma, E. Ricky Chan, Lilei Zhang, Yulan Qing, Stanton L. Gerson, Chen Fu, Anthony Wynshaw-Boris, Panjamaporn Sangwung, Lalitha Nayak, Paul Holvoet, Keiichiro Matoba, Yuan Lu, Guangjin Zhou, Mukesh K. Jain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47134c5fedda43b5b639f09776f89f28
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spelling	oai:doaj.org-article:47134c5fedda43b5b639f09776f89f282021-12-02T16:49:28ZMyeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation10.1038/s41467-020-19760-32041-1723https://doaj.org/article/47134c5fedda43b5b639f09776f89f282020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19760-3https://doaj.org/toc/2041-1723Inflammation contributes to the development of metabolic disease through incompletely understood mechanisms. Here the authors report that deletion of the transcription factor KLF2 in myeloid cells leads to increased feeding and weight gain in mice with concomitant peripheral and central tissue inflammation, while overexpression protects against diet-induced metabolic disease.David R. SweetNeelakantan T. VasudevanLiyan FanChloe E. BoothKomal S. KeerthyXudong LiaoVinesh VinayachandranYoichi TakamiDerin TugalNikunj SharmaE. Ricky ChanLilei ZhangYulan QingStanton L. GersonChen FuAnthony Wynshaw-BorisPanjamaporn SangwungLalitha NayakPaul HolvoetKeiichiro MatobaYuan LuGuangjin ZhouMukesh K. JainNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q David R. Sweet Neelakantan T. Vasudevan Liyan Fan Chloe E. Booth Komal S. Keerthy Xudong Liao Vinesh Vinayachandran Yoichi Takami Derin Tugal Nikunj Sharma E. Ricky Chan Lilei Zhang Yulan Qing Stanton L. Gerson Chen Fu Anthony Wynshaw-Boris Panjamaporn Sangwung Lalitha Nayak Paul Holvoet Keiichiro Matoba Yuan Lu Guangjin Zhou Mukesh K. Jain Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation
description	Inflammation contributes to the development of metabolic disease through incompletely understood mechanisms. Here the authors report that deletion of the transcription factor KLF2 in myeloid cells leads to increased feeding and weight gain in mice with concomitant peripheral and central tissue inflammation, while overexpression protects against diet-induced metabolic disease.
format	article
author	David R. Sweet Neelakantan T. Vasudevan Liyan Fan Chloe E. Booth Komal S. Keerthy Xudong Liao Vinesh Vinayachandran Yoichi Takami Derin Tugal Nikunj Sharma E. Ricky Chan Lilei Zhang Yulan Qing Stanton L. Gerson Chen Fu Anthony Wynshaw-Boris Panjamaporn Sangwung Lalitha Nayak Paul Holvoet Keiichiro Matoba Yuan Lu Guangjin Zhou Mukesh K. Jain
author_facet	David R. Sweet Neelakantan T. Vasudevan Liyan Fan Chloe E. Booth Komal S. Keerthy Xudong Liao Vinesh Vinayachandran Yoichi Takami Derin Tugal Nikunj Sharma E. Ricky Chan Lilei Zhang Yulan Qing Stanton L. Gerson Chen Fu Anthony Wynshaw-Boris Panjamaporn Sangwung Lalitha Nayak Paul Holvoet Keiichiro Matoba Yuan Lu Guangjin Zhou Mukesh K. Jain
author_sort	David R. Sweet
title	Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation
title_short	Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation
title_full	Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation
title_fullStr	Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation
title_full_unstemmed	Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation
title_sort	myeloid krüppel-like factor 2 is a critical regulator of metabolic inflammation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/47134c5fedda43b5b639f09776f89f28
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Myeloid Krüppel-like factor 2 is a critical regulator of metabolic inflammation

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