Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory la...
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2018
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oai:doaj.org-article:471b40b50d8c49149705427b2d4eb93f2021-12-02T14:40:54ZCell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape10.1038/s41467-018-06007-52041-1723https://doaj.org/article/471b40b50d8c49149705427b2d4eb93f2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06007-5https://doaj.org/toc/2041-1723Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape.Paul Adrian GinnoLukas BurgerJan SeebacherVytautas IesmantaviciusDirk SchübelerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q Paul Adrian Ginno Lukas Burger Jan Seebacher Vytautas Iesmantavicius Dirk Schübeler Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape |
description |
Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape. |
format |
article |
author |
Paul Adrian Ginno Lukas Burger Jan Seebacher Vytautas Iesmantavicius Dirk Schübeler |
author_facet |
Paul Adrian Ginno Lukas Burger Jan Seebacher Vytautas Iesmantavicius Dirk Schübeler |
author_sort |
Paul Adrian Ginno |
title |
Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape |
title_short |
Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape |
title_full |
Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape |
title_fullStr |
Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape |
title_full_unstemmed |
Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape |
title_sort |
cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/471b40b50d8c49149705427b2d4eb93f |
work_keys_str_mv |
AT pauladrianginno cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape AT lukasburger cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape AT janseebacher cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape AT vytautasiesmantavicius cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape AT dirkschubeler cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape |
_version_ |
1718390107440939008 |