Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape

Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory la...

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Main Authors:	Paul Adrian Ginno, Lukas Burger, Jan Seebacher, Vytautas Iesmantavicius, Dirk Schübeler
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/471b40b50d8c49149705427b2d4eb93f
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id	oai:doaj.org-article:471b40b50d8c49149705427b2d4eb93f
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spelling	oai:doaj.org-article:471b40b50d8c49149705427b2d4eb93f2021-12-02T14:40:54ZCell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape10.1038/s41467-018-06007-52041-1723https://doaj.org/article/471b40b50d8c49149705427b2d4eb93f2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06007-5https://doaj.org/toc/2041-1723Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape.Paul Adrian GinnoLukas BurgerJan SeebacherVytautas IesmantaviciusDirk SchübelerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Paul Adrian Ginno Lukas Burger Jan Seebacher Vytautas Iesmantavicius Dirk Schübeler Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
description	Mitosis poses a challenge for transcriptional programs, as it is thought that several proteins lose binding on condensed chromosomes. Here, the authors analyze the chromatin-bound proteome through the cell cycle, revealing retention of most transcription factors and preservation of the regulatory landscape.
format	article
author	Paul Adrian Ginno Lukas Burger Jan Seebacher Vytautas Iesmantavicius Dirk Schübeler
author_facet	Paul Adrian Ginno Lukas Burger Jan Seebacher Vytautas Iesmantavicius Dirk Schübeler
author_sort	Paul Adrian Ginno
title	Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
title_short	Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
title_full	Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
title_fullStr	Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
title_full_unstemmed	Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
title_sort	cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/471b40b50d8c49149705427b2d4eb93f
work_keys_str_mv	AT pauladrianginno cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape AT lukasburger cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape AT janseebacher cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape AT vytautasiesmantavicius cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape AT dirkschubeler cellcycleresolvedchromatinproteomicsrevealstheextentofmitoticpreservationofthegenomicregulatorylandscape
_version_	1718390107440939008

Cell cycle-resolved chromatin proteomics reveals the extent of mitotic preservation of the genomic regulatory landscape

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