Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression

Membrane-anchored DNA probes have been used to study molecular interactions and control cell assembly, but are not selective for different cell membranes. Here the authors develop a lipid-conjugated oligonucleotide for alkaline phosphatase-dependent cell membrane anchorage and use it to distinguish...

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Autores principales:	Cheng Jin, Jiaxuan He, Jianmei Zou, Wenjing Xuan, Ting Fu, Ruowen Wang, Weihong Tan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/471b75f32e0f4ee2b944649ab12a7268
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spelling	oai:doaj.org-article:471b75f32e0f4ee2b944649ab12a72682021-12-02T15:36:19ZPhosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression10.1038/s41467-019-10639-62041-1723https://doaj.org/article/471b75f32e0f4ee2b944649ab12a72682019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10639-6https://doaj.org/toc/2041-1723Membrane-anchored DNA probes have been used to study molecular interactions and control cell assembly, but are not selective for different cell membranes. Here the authors develop a lipid-conjugated oligonucleotide for alkaline phosphatase-dependent cell membrane anchorage and use it to distinguish different cancer cells.Cheng JinJiaxuan HeJianmei ZouWenjing XuanTing FuRuowen WangWeihong TanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-7 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cheng Jin Jiaxuan He Jianmei Zou Wenjing Xuan Ting Fu Ruowen Wang Weihong Tan Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
description	Membrane-anchored DNA probes have been used to study molecular interactions and control cell assembly, but are not selective for different cell membranes. Here the authors develop a lipid-conjugated oligonucleotide for alkaline phosphatase-dependent cell membrane anchorage and use it to distinguish different cancer cells.
format	article
author	Cheng Jin Jiaxuan He Jianmei Zou Wenjing Xuan Ting Fu Ruowen Wang Weihong Tan
author_facet	Cheng Jin Jiaxuan He Jianmei Zou Wenjing Xuan Ting Fu Ruowen Wang Weihong Tan
author_sort	Cheng Jin
title	Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
title_short	Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
title_full	Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
title_fullStr	Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
title_full_unstemmed	Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
title_sort	phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/471b75f32e0f4ee2b944649ab12a7268
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_version_	1718386285916192768

Phosphorylated lipid-conjugated oligonucleotide selectively anchors on cell membranes with high alkaline phosphatase expression

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