Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development

Transcriptomic analysis often doesn’t differentiate between newly synthesized and stabilized mRNAs. Using rapid 4-thiouracil incorporation, Painter et al. here define genome-wide active transcription throughout Plasmodium blood-stage developmental stages and identify associated regulatory DNA sequen...

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Autores principales:	Heather J. Painter, Neo Christopher Chung, Aswathy Sebastian, Istvan Albert, John D. Storey, Manuel Llinás
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/471c5b2d6a8242d18183098b891f0b24
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id	oai:doaj.org-article:471c5b2d6a8242d18183098b891f0b24
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spelling	oai:doaj.org-article:471c5b2d6a8242d18183098b891f0b242021-12-02T16:49:34ZGenome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development10.1038/s41467-018-04966-32041-1723https://doaj.org/article/471c5b2d6a8242d18183098b891f0b242018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04966-3https://doaj.org/toc/2041-1723Transcriptomic analysis often doesn’t differentiate between newly synthesized and stabilized mRNAs. Using rapid 4-thiouracil incorporation, Painter et al. here define genome-wide active transcription throughout Plasmodium blood-stage developmental stages and identify associated regulatory DNA sequence motifs.Heather J. PainterNeo Christopher ChungAswathy SebastianIstvan AlbertJohn D. StoreyManuel LlinásNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Heather J. Painter Neo Christopher Chung Aswathy Sebastian Istvan Albert John D. Storey Manuel Llinás Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development
description	Transcriptomic analysis often doesn’t differentiate between newly synthesized and stabilized mRNAs. Using rapid 4-thiouracil incorporation, Painter et al. here define genome-wide active transcription throughout Plasmodium blood-stage developmental stages and identify associated regulatory DNA sequence motifs.
format	article
author	Heather J. Painter Neo Christopher Chung Aswathy Sebastian Istvan Albert John D. Storey Manuel Llinás
author_facet	Heather J. Painter Neo Christopher Chung Aswathy Sebastian Istvan Albert John D. Storey Manuel Llinás
author_sort	Heather J. Painter
title	Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development
title_short	Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development
title_full	Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development
title_fullStr	Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development
title_full_unstemmed	Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development
title_sort	genome-wide real-time in vivo transcriptional dynamics during plasmodium falciparum blood-stage development
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/471c5b2d6a8242d18183098b891f0b24
work_keys_str_mv	AT heatherjpainter genomewiderealtimeinvivotranscriptionaldynamicsduringplasmodiumfalciparumbloodstagedevelopment AT neochristopherchung genomewiderealtimeinvivotranscriptionaldynamicsduringplasmodiumfalciparumbloodstagedevelopment AT aswathysebastian genomewiderealtimeinvivotranscriptionaldynamicsduringplasmodiumfalciparumbloodstagedevelopment AT istvanalbert genomewiderealtimeinvivotranscriptionaldynamicsduringplasmodiumfalciparumbloodstagedevelopment AT johndstorey genomewiderealtimeinvivotranscriptionaldynamicsduringplasmodiumfalciparumbloodstagedevelopment AT manuelllinas genomewiderealtimeinvivotranscriptionaldynamicsduringplasmodiumfalciparumbloodstagedevelopment
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Genome-wide real-time in vivo transcriptional dynamics during Plasmodium falciparum blood-stage development

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