Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study

Yingchan Wang,1,* Yuchao Jiang,2,* Wenjun Su,1 Lihua Xu,1 Yanyan Wei,1 Yingying Tang,1 Tianhong Zhang,1 Xiaochen Tang,1 Yegang Hu,1 Huiru Cui,1 Jinhong Wang,1 Dezhong Yao,2 Cheng Luo,2 Jijun Wang1,3,4 1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong...

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Autores principales:	Wang Y, Jiang Y, Su W, Xu L, Wei Y, Tang Y, Zhang T, Tang X, Hu Y, Cui H, Wang J, Yao D, Luo C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	schizophrenia degree centrality dynamics resting-state functional magnetic resonance imaging treatment response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/4721d1a8d7bd4d3a96499125483d3a5d
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spelling	oai:doaj.org-article:4721d1a8d7bd4d3a96499125483d3a5d2021-12-02T17:16:49ZTemporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study1178-2021https://doaj.org/article/4721d1a8d7bd4d3a96499125483d3a5d2021-05-01T00:00:00Zhttps://www.dovepress.com/temporal-dynamics-in-degree-centrality-of-brain-functional-connectome--peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Yingchan Wang,1,* Yuchao Jiang,2,* Wenjun Su,1 Lihua Xu,1 Yanyan Wei,1 Yingying Tang,1 Tianhong Zhang,1 Xiaochen Tang,1 Yegang Hu,1 Huiru Cui,1 Jinhong Wang,1 Dezhong Yao,2 Cheng Luo,2 Jijun Wang1,3,4 1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People’s Republic of China; 2The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, 610054, People’s Republic of China; 3CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, 200031, People’s Republic of China; 4Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jijun WangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People’s Republic of ChinaTel +86 21 3428 9888Fax +86 21 6438 7986Email jjijunwang27@163.comPurpose: This study investigated temporal dynamics in degree centrality (DC) of the brain functional connectome in first-episode schizophrenia with different short-term treatment responses.Methods: A total of 127 first-episode patients (FEPs) with schizophrenia and 133 healthy controls (HCs) were recruited in this study. All subjects underwent resting-state functional magnetic resonance imaging. FEPs were scanned at baseline (pretreatment) and at follow-up (posttreatment), while HCs were scanned only at baseline. The patients were exposed to naturalistic antipsychotic treatment for 12 weeks, and classified as schizophrenia responders (SRs) or nonresponders (NRs). Voxel-wise dynamic DC analyses were conducted among the SRs (n=75), NRs (n=52), and HCs (n=133) to assess temporal variability in functional connectivity across the entire neuronal network.Results: The SRs and NRs showed dissimilar dynamic DC at baseline, with differences mainly involving the temporal lobe. Different DC alteration was observed in the left fusiform gyrus, right fusiform gyrus, left middle cingulate cortex, and left superior parietal gyrus in the SRs and NRs pre- and posttreatment. SRs group and NRs presented opposite changing patterns of dynamic DC in particular regions of the brain.Conclusion: These findings indicate that dynamic DC abnormalities exist in unmedicated patients with schizophrenia. The NRs differed from the SRs in dynamic DC not only at baseline but in the characteristics of changes before and after treatment as well. Our study may contribute to understanding pathophysiology in schizophrenia with different treatment responses.Keywords: schizophrenia, degree centrality, dynamics, resting-state functional magnetic resonance imaging, treatment responseWang YJiang YSu WXu LWei YTang YZhang TTang XHu YCui HWang JYao DLuo CWang JDove Medical Pressarticleschizophreniadegree centralitydynamicsresting-state functional magnetic resonance imagingtreatment responseNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 1505-1516 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	schizophrenia degree centrality dynamics resting-state functional magnetic resonance imaging treatment response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	schizophrenia degree centrality dynamics resting-state functional magnetic resonance imaging treatment response Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Wang Y Jiang Y Su W Xu L Wei Y Tang Y Zhang T Tang X Hu Y Cui H Wang J Yao D Luo C Wang J Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study
description	Yingchan Wang,1,* Yuchao Jiang,2,* Wenjun Su,1 Lihua Xu,1 Yanyan Wei,1 Yingying Tang,1 Tianhong Zhang,1 Xiaochen Tang,1 Yegang Hu,1 Huiru Cui,1 Jinhong Wang,1 Dezhong Yao,2 Cheng Luo,2 Jijun Wang1,3,4 1Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People’s Republic of China; 2The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, Center for Information in Medicine, School of life Science and technology, University of Electronic Science and Technology of China, Chengdu, 610054, People’s Republic of China; 3CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, 200031, People’s Republic of China; 4Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jijun WangShanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People’s Republic of ChinaTel +86 21 3428 9888Fax +86 21 6438 7986Email jjijunwang27@163.comPurpose: This study investigated temporal dynamics in degree centrality (DC) of the brain functional connectome in first-episode schizophrenia with different short-term treatment responses.Methods: A total of 127 first-episode patients (FEPs) with schizophrenia and 133 healthy controls (HCs) were recruited in this study. All subjects underwent resting-state functional magnetic resonance imaging. FEPs were scanned at baseline (pretreatment) and at follow-up (posttreatment), while HCs were scanned only at baseline. The patients were exposed to naturalistic antipsychotic treatment for 12 weeks, and classified as schizophrenia responders (SRs) or nonresponders (NRs). Voxel-wise dynamic DC analyses were conducted among the SRs (n=75), NRs (n=52), and HCs (n=133) to assess temporal variability in functional connectivity across the entire neuronal network.Results: The SRs and NRs showed dissimilar dynamic DC at baseline, with differences mainly involving the temporal lobe. Different DC alteration was observed in the left fusiform gyrus, right fusiform gyrus, left middle cingulate cortex, and left superior parietal gyrus in the SRs and NRs pre- and posttreatment. SRs group and NRs presented opposite changing patterns of dynamic DC in particular regions of the brain.Conclusion: These findings indicate that dynamic DC abnormalities exist in unmedicated patients with schizophrenia. The NRs differed from the SRs in dynamic DC not only at baseline but in the characteristics of changes before and after treatment as well. Our study may contribute to understanding pathophysiology in schizophrenia with different treatment responses.Keywords: schizophrenia, degree centrality, dynamics, resting-state functional magnetic resonance imaging, treatment response
format	article
author	Wang Y Jiang Y Su W Xu L Wei Y Tang Y Zhang T Tang X Hu Y Cui H Wang J Yao D Luo C Wang J
author_facet	Wang Y Jiang Y Su W Xu L Wei Y Tang Y Zhang T Tang X Hu Y Cui H Wang J Yao D Luo C Wang J
author_sort	Wang Y
title	Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study
title_short	Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study
title_full	Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study
title_fullStr	Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study
title_full_unstemmed	Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study
title_sort	temporal dynamics in degree centrality of brain functional connectome in first-episode schizophrenia with different short-term treatment responses: a longitudinal study
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/4721d1a8d7bd4d3a96499125483d3a5d
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Temporal Dynamics in Degree Centrality of Brain Functional Connectome in First-Episode Schizophrenia with Different Short-Term Treatment Responses: A Longitudinal Study

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