Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.

<h4>Background</h4>Vitamin C is associated with a lower risk of coronary heart disease possibly due to its anti-oxidative effects, beneficial effects on endothelial function and importance in collagen synthesis. The sodium-dependent vitamin C transporter 2 is responsible for the transpor...

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Autores principales:	Christine Dalgård, Lene Christiansen, Ulla Vogel, Claus Dethlefsen, Anne Tjønneland, Kim Overvad
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47291676478b426794c84a384272bbab
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spelling	oai:doaj.org-article:47291676478b426794c84a384272bbab2021-11-18T08:58:40ZVariation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.1932-620310.1371/journal.pone.0070421https://doaj.org/article/47291676478b426794c84a384272bbab2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23990905/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Vitamin C is associated with a lower risk of coronary heart disease possibly due to its anti-oxidative effects, beneficial effects on endothelial function and importance in collagen synthesis. The sodium-dependent vitamin C transporter 2 is responsible for the transport of vitamin C into various cells and malfunction of this protein leads to reduced vitamin C in tissue, including the arterial wall. We tested the hypothesis that candidate variations rs6139591 and rs1776964 in the gene coding for sodium-dependent vitamin C transporter 2 are associated with development of acute coronary syndrome.<h4>Design</h4>In the Danish Diet, Cancer and Health cohort study, we performed a case-cohort study among 57,053 subjects aged 50-64 years.<h4>Results</h4>During a mean follow-up period of 6.4 years, we identified 936 cases and randomly selected a sub-cohort (n = 1,580) with full information on genotypes and covariates. Using Cox proportional hazard models, we found that women with the rs6139591 TT genotype and a lower than median dietary vitamin C intake had a higher risk of acute coronary syndrome compared with those with the CC genotype (adjusted HR 5.39, 95% confidence interval, 2.01-14.50). We also observed a not as strong but positive although inconsistent association for women at a higher than median intake of vitamin C rich food. For the rs1776964 polymorphism, we found a higher risk (adjusted HR 3.45, 95% CI, 1.16-10.28) among TT-homozygous women with higher than median vitamin C intake compared with the CC genotype and low vitamin C intake. Among men, weaker and non-significant associations were observed for both polymorphisms.<h4>Conclusion</h4>Genetic variation in the sodium-dependent vitamin C transporter 2 is associated with risk of incident acute coronary syndrome in women. The genotype effects may not be fully compensated by a higher intake of vitamin C rich food.Christine DalgårdLene ChristiansenUlla VogelClaus DethlefsenAnne TjønnelandKim OvervadPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e70421 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Christine Dalgård Lene Christiansen Ulla Vogel Claus Dethlefsen Anne Tjønneland Kim Overvad Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.
description	<h4>Background</h4>Vitamin C is associated with a lower risk of coronary heart disease possibly due to its anti-oxidative effects, beneficial effects on endothelial function and importance in collagen synthesis. The sodium-dependent vitamin C transporter 2 is responsible for the transport of vitamin C into various cells and malfunction of this protein leads to reduced vitamin C in tissue, including the arterial wall. We tested the hypothesis that candidate variations rs6139591 and rs1776964 in the gene coding for sodium-dependent vitamin C transporter 2 are associated with development of acute coronary syndrome.<h4>Design</h4>In the Danish Diet, Cancer and Health cohort study, we performed a case-cohort study among 57,053 subjects aged 50-64 years.<h4>Results</h4>During a mean follow-up period of 6.4 years, we identified 936 cases and randomly selected a sub-cohort (n = 1,580) with full information on genotypes and covariates. Using Cox proportional hazard models, we found that women with the rs6139591 TT genotype and a lower than median dietary vitamin C intake had a higher risk of acute coronary syndrome compared with those with the CC genotype (adjusted HR 5.39, 95% confidence interval, 2.01-14.50). We also observed a not as strong but positive although inconsistent association for women at a higher than median intake of vitamin C rich food. For the rs1776964 polymorphism, we found a higher risk (adjusted HR 3.45, 95% CI, 1.16-10.28) among TT-homozygous women with higher than median vitamin C intake compared with the CC genotype and low vitamin C intake. Among men, weaker and non-significant associations were observed for both polymorphisms.<h4>Conclusion</h4>Genetic variation in the sodium-dependent vitamin C transporter 2 is associated with risk of incident acute coronary syndrome in women. The genotype effects may not be fully compensated by a higher intake of vitamin C rich food.
format	article
author	Christine Dalgård Lene Christiansen Ulla Vogel Claus Dethlefsen Anne Tjønneland Kim Overvad
author_facet	Christine Dalgård Lene Christiansen Ulla Vogel Claus Dethlefsen Anne Tjønneland Kim Overvad
author_sort	Christine Dalgård
title	Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.
title_short	Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.
title_full	Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.
title_fullStr	Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.
title_full_unstemmed	Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.
title_sort	variation in the sodium-dependent vitamin c transporter 2 gene is associated with risk of acute coronary syndrome among women.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/47291676478b426794c84a384272bbab
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Variation in the sodium-dependent vitamin C transporter 2 gene is associated with risk of acute coronary syndrome among women.

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