Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel

Prolyl isomerization controls activation kinetics of a cyclic nucleotide-gated ion channel

SthK, a cyclic nucleotide-gated ion channel from Spirochaeta thermophila activates slowly upon cAMP increase. Here, authors investigate cAMP-induced activation in purified SthK channels using stopped-flow assays and enzymatic catalysis and reveal that the cis/trans conformation of a conserved prolin...

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Autores principales: Philipp A. M. Schmidpeter, Jan Rheinberger, Crina M. Nimigean
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/472b03d2ec91449c83984880c8a21003
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