REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION

The paper presents evidence that the susceptibility of monocyte-derived cells to the Hantaviral infection increases when they reach the final stage of differentiation. In view of the phylogenetic homogeneity of these cells, the data obtained in the study of their interaction with Hantavirus can be e...

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Autores principales:	N. G. Plekhova, I. N. Lyapun, L. M. Somova, G. G. Kompanets, I. N. Smirnov
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2012
Materias:	monocytes macrophages neutrophils viral infection ultrastructure metabolism of cell Science Q
Acceso en línea:	https://doaj.org/article/472fa3758da247bf8932a9915c8d0a13
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spelling	oai:doaj.org-article:472fa3758da247bf8932a9915c8d0a132021-11-23T06:14:20ZREACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION2541-94202587-9596https://doaj.org/article/472fa3758da247bf8932a9915c8d0a132012-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/938https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The paper presents evidence that the susceptibility of monocyte-derived cells to the Hantaviral infection increases when they reach the final stage of differentiation. In view of the phylogenetic homogeneity of these cells, the data obtained in the study of their interaction with Hantavirus can be extrapolated to monocytic cells of origin of mammals. It is indicated that Hantaviruses are resistant to the effects of monocytes/macrophages and are capable of intracellular replication in them breaking thus the biological barrier preventing the spread of the pathogen from the primary site of infection and protects against infected sensitive cells of various organs. With respect of neutrophils revealed that hantavirus showing cytopathogenic properties, as indicated by the appearance of apoptotic cells and modified periods of reduced viability of the cell culture.N. G. PlekhovaI. N. LyapunL. M. SomovaG. G. KompanetsI. N. SmirnovScientific Сentre for Family Health and Human Reproduction Problemsarticlemonocytesmacrophagesneutrophilsviral infectionultrastructuremetabolism of cellScienceQRUActa Biomedica Scientifica, Vol 0, Iss 3(2), Pp 297-300 (2012)
institution	DOAJ
collection	DOAJ
language	RU
topic	monocytes macrophages neutrophils viral infection ultrastructure metabolism of cell Science Q
spellingShingle	monocytes macrophages neutrophils viral infection ultrastructure metabolism of cell Science Q N. G. Plekhova I. N. Lyapun L. M. Somova G. G. Kompanets I. N. Smirnov REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION
description	The paper presents evidence that the susceptibility of monocyte-derived cells to the Hantaviral infection increases when they reach the final stage of differentiation. In view of the phylogenetic homogeneity of these cells, the data obtained in the study of their interaction with Hantavirus can be extrapolated to monocytic cells of origin of mammals. It is indicated that Hantaviruses are resistant to the effects of monocytes/macrophages and are capable of intracellular replication in them breaking thus the biological barrier preventing the spread of the pathogen from the primary site of infection and protects against infected sensitive cells of various organs. With respect of neutrophils revealed that hantavirus showing cytopathogenic properties, as indicated by the appearance of apoptotic cells and modified periods of reduced viability of the cell culture.
format	article
author	N. G. Plekhova I. N. Lyapun L. M. Somova G. G. Kompanets I. N. Smirnov
author_facet	N. G. Plekhova I. N. Lyapun L. M. Somova G. G. Kompanets I. N. Smirnov
author_sort	N. G. Plekhova
title	REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION
title_short	REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION
title_full	REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION
title_fullStr	REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION
title_full_unstemmed	REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION
title_sort	reactivity of cells innate immunity in the pathogenesis of hantaviral infection
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2012
url	https://doaj.org/article/472fa3758da247bf8932a9915c8d0a13
work_keys_str_mv	AT ngplekhova reactivityofcellsinnateimmunityinthepathogenesisofhantaviralinfection AT inlyapun reactivityofcellsinnateimmunityinthepathogenesisofhantaviralinfection AT lmsomova reactivityofcellsinnateimmunityinthepathogenesisofhantaviralinfection AT ggkompanets reactivityofcellsinnateimmunityinthepathogenesisofhantaviralinfection AT insmirnov reactivityofcellsinnateimmunityinthepathogenesisofhantaviralinfection
_version_	1718417249673412608

REACTIVITY OF CELLS INNATE IMMUNITY IN THE PATHOGENESIS OF HANTAVIRAL INFECTION

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