Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis

Prolyl hydroxylase domain protein 2 (PHD2) regulates cellular response to hypoxia. Here the authors show that PHD2 is downregulated in melanoma and that PHD2 depletion, in a mouse model, promotes the progression of benign melanocytic lesions into melanoma, via activation of the Akt/mTOR signaling ca...

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Autores principales:	Shujing Liu, Gao Zhang, Jianping Guo, Xiang Chen, Jingce Lei, Kan Ze, Liyun Dong, Xiangpeng Dai, Yang Gao, Daisheng Song, Brett L. Ecker, Ruifeng Yang, Caitlin Feltcher, Kai Peng, Cheng Feng, Hui Chen, Rebecca X. Lee, Heddy Kerestes, Jingwen Niu, Suresh Kumar, Weiting Xu, Jie Zhang, Zhi Wei, James S. Martin, Xiaoming Liu, Gordon Mills, Yiling Lu, Wei Guo, Lunquan Sun, Lin Zhang, Ashani Weeraratna, Meenhard Herlyn, Wenyi Wei, Frank S. Lee, Xiaowei Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/473123c7d99e44289a92d2ad275cec64
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spelling	oai:doaj.org-article:473123c7d99e44289a92d2ad275cec642021-12-02T17:31:44ZLoss of Phd2 cooperates with BRAF V600E to drive melanomagenesis10.1038/s41467-018-07126-92041-1723https://doaj.org/article/473123c7d99e44289a92d2ad275cec642018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07126-9https://doaj.org/toc/2041-1723Prolyl hydroxylase domain protein 2 (PHD2) regulates cellular response to hypoxia. Here the authors show that PHD2 is downregulated in melanoma and that PHD2 depletion, in a mouse model, promotes the progression of benign melanocytic lesions into melanoma, via activation of the Akt/mTOR signaling cascade.Shujing LiuGao ZhangJianping GuoXiang ChenJingce LeiKan ZeLiyun DongXiangpeng DaiYang GaoDaisheng SongBrett L. EckerRuifeng YangCaitlin FeltcherKai PengCheng FengHui ChenRebecca X. LeeHeddy KerestesJingwen NiuSuresh KumarWeiting XuJie ZhangZhi WeiJames S. MartinXiaoming LiuGordon MillsYiling LuWei GuoLunquan SunLin ZhangAshani WeeraratnaMeenhard HerlynWenyi WeiFrank S. LeeXiaowei XuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shujing Liu Gao Zhang Jianping Guo Xiang Chen Jingce Lei Kan Ze Liyun Dong Xiangpeng Dai Yang Gao Daisheng Song Brett L. Ecker Ruifeng Yang Caitlin Feltcher Kai Peng Cheng Feng Hui Chen Rebecca X. Lee Heddy Kerestes Jingwen Niu Suresh Kumar Weiting Xu Jie Zhang Zhi Wei James S. Martin Xiaoming Liu Gordon Mills Yiling Lu Wei Guo Lunquan Sun Lin Zhang Ashani Weeraratna Meenhard Herlyn Wenyi Wei Frank S. Lee Xiaowei Xu Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
description	Prolyl hydroxylase domain protein 2 (PHD2) regulates cellular response to hypoxia. Here the authors show that PHD2 is downregulated in melanoma and that PHD2 depletion, in a mouse model, promotes the progression of benign melanocytic lesions into melanoma, via activation of the Akt/mTOR signaling cascade.
format	article
author	Shujing Liu Gao Zhang Jianping Guo Xiang Chen Jingce Lei Kan Ze Liyun Dong Xiangpeng Dai Yang Gao Daisheng Song Brett L. Ecker Ruifeng Yang Caitlin Feltcher Kai Peng Cheng Feng Hui Chen Rebecca X. Lee Heddy Kerestes Jingwen Niu Suresh Kumar Weiting Xu Jie Zhang Zhi Wei James S. Martin Xiaoming Liu Gordon Mills Yiling Lu Wei Guo Lunquan Sun Lin Zhang Ashani Weeraratna Meenhard Herlyn Wenyi Wei Frank S. Lee Xiaowei Xu
author_facet	Shujing Liu Gao Zhang Jianping Guo Xiang Chen Jingce Lei Kan Ze Liyun Dong Xiangpeng Dai Yang Gao Daisheng Song Brett L. Ecker Ruifeng Yang Caitlin Feltcher Kai Peng Cheng Feng Hui Chen Rebecca X. Lee Heddy Kerestes Jingwen Niu Suresh Kumar Weiting Xu Jie Zhang Zhi Wei James S. Martin Xiaoming Liu Gordon Mills Yiling Lu Wei Guo Lunquan Sun Lin Zhang Ashani Weeraratna Meenhard Herlyn Wenyi Wei Frank S. Lee Xiaowei Xu
author_sort	Shujing Liu
title	Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
title_short	Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
title_full	Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
title_fullStr	Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
title_full_unstemmed	Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis
title_sort	loss of phd2 cooperates with braf v600e to drive melanomagenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/473123c7d99e44289a92d2ad275cec64
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Loss of Phd2 cooperates with BRAF V600E to drive melanomagenesis

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