TOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis

Summary: Spermidine (Spd) is a nitrogen sink and signaling molecule that plays pivotal roles in eukaryotic cell growth and must be finetuned to meet various energy demands. In eukaryotes, target of rapamycin (TOR) is a central nutrient sensor, especially N, and a master-regulator of growth and devel...

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Autores principales:	Kenia Salazar-Díaz, Yihan Dong, Csaba Papdi, Ernesto Miguel Ferruzca-Rubio, Grecia Olea-Badillo, Lyubov A. Ryabova, Tzvetanka D. Dinkova
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	cell biology plant biology plant physiology Science Q
Acceso en línea:	https://doaj.org/article/4733fd74ffdc42718151b812ab03e21d
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spelling	oai:doaj.org-article:4733fd74ffdc42718151b812ab03e21d2021-11-20T05:08:59ZTOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis2589-004210.1016/j.isci.2021.103260https://doaj.org/article/4733fd74ffdc42718151b812ab03e21d2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2589004221012293https://doaj.org/toc/2589-0042Summary: Spermidine (Spd) is a nitrogen sink and signaling molecule that plays pivotal roles in eukaryotic cell growth and must be finetuned to meet various energy demands. In eukaryotes, target of rapamycin (TOR) is a central nutrient sensor, especially N, and a master-regulator of growth and development. Here, we discovered that Spd stimulates the growth of maize and Arabidopsis seedlings through TOR signaling. Inhibition of Spd biosynthesis led to TOR inactivation and growth defects. Furthermore, disruption of a TOR complex partner RAPTOR1B abolished seedling growth stimulation by Spd. Strikingly, TOR activated by Spd promotes translation of key metabolic enzyme upstream open reading frame (uORF)-containing mRNAs, PAO and CuAO, by facilitating translation reinitiation and providing feedback to polyamine metabolism and TOR activation. The Spd-TOR relay protected young-age seedlings of maize from expeditious stress heat shock. Our results demonstrate Spd is an upstream effector of TOR kinase in planta and provide its potential application for crop protection.Kenia Salazar-DíazYihan DongCsaba PapdiErnesto Miguel Ferruzca-RubioGrecia Olea-BadilloLyubov A. RyabovaTzvetanka D. DinkovaElsevierarticlecell biologyplant biologyplant physiologyScienceQENiScience, Vol 24, Iss 11, Pp 103260- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell biology plant biology plant physiology Science Q
spellingShingle	cell biology plant biology plant physiology Science Q Kenia Salazar-Díaz Yihan Dong Csaba Papdi Ernesto Miguel Ferruzca-Rubio Grecia Olea-Badillo Lyubov A. Ryabova Tzvetanka D. Dinkova TOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis
description	Summary: Spermidine (Spd) is a nitrogen sink and signaling molecule that plays pivotal roles in eukaryotic cell growth and must be finetuned to meet various energy demands. In eukaryotes, target of rapamycin (TOR) is a central nutrient sensor, especially N, and a master-regulator of growth and development. Here, we discovered that Spd stimulates the growth of maize and Arabidopsis seedlings through TOR signaling. Inhibition of Spd biosynthesis led to TOR inactivation and growth defects. Furthermore, disruption of a TOR complex partner RAPTOR1B abolished seedling growth stimulation by Spd. Strikingly, TOR activated by Spd promotes translation of key metabolic enzyme upstream open reading frame (uORF)-containing mRNAs, PAO and CuAO, by facilitating translation reinitiation and providing feedback to polyamine metabolism and TOR activation. The Spd-TOR relay protected young-age seedlings of maize from expeditious stress heat shock. Our results demonstrate Spd is an upstream effector of TOR kinase in planta and provide its potential application for crop protection.
format	article
author	Kenia Salazar-Díaz Yihan Dong Csaba Papdi Ernesto Miguel Ferruzca-Rubio Grecia Olea-Badillo Lyubov A. Ryabova Tzvetanka D. Dinkova
author_facet	Kenia Salazar-Díaz Yihan Dong Csaba Papdi Ernesto Miguel Ferruzca-Rubio Grecia Olea-Badillo Lyubov A. Ryabova Tzvetanka D. Dinkova
author_sort	Kenia Salazar-Díaz
title	TOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis
title_short	TOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis
title_full	TOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis
title_fullStr	TOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis
title_full_unstemmed	TOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis
title_sort	tor senses and regulates spermidine metabolism during seedling establishment and growth in maize and arabidopsis
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/4733fd74ffdc42718151b812ab03e21d
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_version_	1718419537937825792

TOR senses and regulates spermidine metabolism during seedling establishment and growth in maize and Arabidopsis

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