Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats

Background: Paricalcitol has been proposed for the treatment of secondary hyperparathyroidism in patients with renal failure and vitamin D deficiency (VDD); however, VDD is related to a range of clinical complaints. We aimed to investigate the effects of paricalcitol on body composition in VDD rats....

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Autores principales:	Farhad Koohpeyma, Gholamhossein Ranjbar Omrani, Ali Zamani, Forough Saki
Formato:	article
Lenguaje:	EN
Publicado:	Shiraz University of Medical Sciences 2021
Materias:	body composition vitamin d calcium rats Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/4735428350e346968cac2a38fa005723
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spelling	oai:doaj.org-article:4735428350e346968cac2a38fa0057232021-11-09T06:23:38ZEffects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats0253-07161735-368810.30476/ijms.2020.85368.1503https://doaj.org/article/4735428350e346968cac2a38fa0057232021-11-01T00:00:00Zhttps://ijms.sums.ac.ir/article_47521_6adfa6cca657075b3d1ebfad5727359a.pdfhttps://doaj.org/toc/0253-0716https://doaj.org/toc/1735-3688Background: Paricalcitol has been proposed for the treatment of secondary hyperparathyroidism in patients with renal failure and vitamin D deficiency (VDD); however, VDD is related to a range of clinical complaints. We aimed to investigate the effects of paricalcitol on body composition in VDD rats.Methods: Thirty adult male rats aged 10 weeks were randomly divided into three groups of 10, comprising control, VDD, and VDD plus paricalcitol (32 ng/rat intraperitoneal injection) (VDD+P), at the Animal Lab of the Endocrinology and Metabolism Research Center, Shiraz, Iran, in 2020. Body composition was assessed after three weeks via serum biochemical tests and dual-energy X-ray absorptiometry. Finally, the data were analyzed by using the paired-sample t test, the one-way ANOVA, and the Tukey post hoc test.Results: Global lean mass and fat mass were lower in the VDD and VDD+P groups than in the controls (P<0.001). Global fat percentage was reduced significantly in the VDD+P group (P=0.029).Conclusion: Paricalcitol reduced global fat mass and fat percentage in a rat model with VDD. Evaluation of insulin and adiponectin levels is suggested to clarify the physiology of paricalcitol in VDD states.Farhad KoohpeymaGholamhossein Ranjbar OmraniAli ZamaniForough SakiShiraz University of Medical Sciencesarticlebody compositionvitamin dcalciumratsMedicine (General)R5-920ENIranian Journal of Medical Sciences, Vol 46, Iss 6, Pp 468-474 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	body composition vitamin d calcium rats Medicine (General) R5-920
spellingShingle	body composition vitamin d calcium rats Medicine (General) R5-920 Farhad Koohpeyma Gholamhossein Ranjbar Omrani Ali Zamani Forough Saki Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats
description	Background: Paricalcitol has been proposed for the treatment of secondary hyperparathyroidism in patients with renal failure and vitamin D deficiency (VDD); however, VDD is related to a range of clinical complaints. We aimed to investigate the effects of paricalcitol on body composition in VDD rats.Methods: Thirty adult male rats aged 10 weeks were randomly divided into three groups of 10, comprising control, VDD, and VDD plus paricalcitol (32 ng/rat intraperitoneal injection) (VDD+P), at the Animal Lab of the Endocrinology and Metabolism Research Center, Shiraz, Iran, in 2020. Body composition was assessed after three weeks via serum biochemical tests and dual-energy X-ray absorptiometry. Finally, the data were analyzed by using the paired-sample t test, the one-way ANOVA, and the Tukey post hoc test.Results: Global lean mass and fat mass were lower in the VDD and VDD+P groups than in the controls (P<0.001). Global fat percentage was reduced significantly in the VDD+P group (P=0.029).Conclusion: Paricalcitol reduced global fat mass and fat percentage in a rat model with VDD. Evaluation of insulin and adiponectin levels is suggested to clarify the physiology of paricalcitol in VDD states.
format	article
author	Farhad Koohpeyma Gholamhossein Ranjbar Omrani Ali Zamani Forough Saki
author_facet	Farhad Koohpeyma Gholamhossein Ranjbar Omrani Ali Zamani Forough Saki
author_sort	Farhad Koohpeyma
title	Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats
title_short	Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats
title_full	Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats
title_fullStr	Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats
title_full_unstemmed	Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats
title_sort	effects of paricalcitol on body composition in vitamin d-deficient rats
publisher	Shiraz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/4735428350e346968cac2a38fa005723
work_keys_str_mv	AT farhadkoohpeyma effectsofparicalcitolonbodycompositioninvitaminddeficientrats AT gholamhosseinranjbaromrani effectsofparicalcitolonbodycompositioninvitaminddeficientrats AT alizamani effectsofparicalcitolonbodycompositioninvitaminddeficientrats AT foroughsaki effectsofparicalcitolonbodycompositioninvitaminddeficientrats
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Effects of Paricalcitol on Body Composition in Vitamin D-Deficient Rats

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