Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer

The molecular mechanism underlying the resistance of AKT inhibitors in breast cancer is still elusive. Here, the authors demonstrate that BRD4/FOXO3a axis upregulates CDK6 promoter activity to promote resistance to AKT inhibition in breast cancer cells and that blocking the action of CDK6 re-sensiti...

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Autores principales:	Jingyi Liu, Zhibing Duan, Weijie Guo, Lei Zeng, Yadi Wu, Yule Chen, Fang Tai, Yifan Wang, Yiwei Lin, Qiang Zhang, Yanling He, Jiong Deng, Rachel L. Stewart, Chi Wang, Pengnian Charles Lin, Saghi Ghaffari, B. Mark Evers, Suling Liu, Ming-Ming Zhou, Binhua P. Zhou, Jian Shi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47361ecca973405cbbf1642486398298
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spelling	oai:doaj.org-article:47361ecca973405cbbf16424863982982021-12-02T15:33:45ZTargeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer10.1038/s41467-018-07258-y2041-1723https://doaj.org/article/47361ecca973405cbbf16424863982982018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07258-yhttps://doaj.org/toc/2041-1723The molecular mechanism underlying the resistance of AKT inhibitors in breast cancer is still elusive. Here, the authors demonstrate that BRD4/FOXO3a axis upregulates CDK6 promoter activity to promote resistance to AKT inhibition in breast cancer cells and that blocking the action of CDK6 re-sensitizes resistant cancer cells to growth inhibition.Jingyi LiuZhibing DuanWeijie GuoLei ZengYadi WuYule ChenFang TaiYifan WangYiwei LinQiang ZhangYanling HeJiong DengRachel L. StewartChi WangPengnian Charles LinSaghi GhaffariB. Mark EversSuling LiuMing-Ming ZhouBinhua P. ZhouJian ShiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jingyi Liu Zhibing Duan Weijie Guo Lei Zeng Yadi Wu Yule Chen Fang Tai Yifan Wang Yiwei Lin Qiang Zhang Yanling He Jiong Deng Rachel L. Stewart Chi Wang Pengnian Charles Lin Saghi Ghaffari B. Mark Evers Suling Liu Ming-Ming Zhou Binhua P. Zhou Jian Shi Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
description	The molecular mechanism underlying the resistance of AKT inhibitors in breast cancer is still elusive. Here, the authors demonstrate that BRD4/FOXO3a axis upregulates CDK6 promoter activity to promote resistance to AKT inhibition in breast cancer cells and that blocking the action of CDK6 re-sensitizes resistant cancer cells to growth inhibition.
format	article
author	Jingyi Liu Zhibing Duan Weijie Guo Lei Zeng Yadi Wu Yule Chen Fang Tai Yifan Wang Yiwei Lin Qiang Zhang Yanling He Jiong Deng Rachel L. Stewart Chi Wang Pengnian Charles Lin Saghi Ghaffari B. Mark Evers Suling Liu Ming-Ming Zhou Binhua P. Zhou Jian Shi
author_facet	Jingyi Liu Zhibing Duan Weijie Guo Lei Zeng Yadi Wu Yule Chen Fang Tai Yifan Wang Yiwei Lin Qiang Zhang Yanling He Jiong Deng Rachel L. Stewart Chi Wang Pengnian Charles Lin Saghi Ghaffari B. Mark Evers Suling Liu Ming-Ming Zhou Binhua P. Zhou Jian Shi
author_sort	Jingyi Liu
title	Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
title_short	Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
title_full	Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
title_fullStr	Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
title_full_unstemmed	Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer
title_sort	targeting the brd4/foxo3a/cdk6 axis sensitizes akt inhibition in luminal breast cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/47361ecca973405cbbf1642486398298
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Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer

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