Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.

Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin's lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports hav...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cristina Robledo, Juan L García, Rocío Benito, Teresa Flores, Manuela Mollejo, José Ángel Martínez-Climent, Eva García, Norma C Gutiérrez, Miguel A Piris, Jesús M Hernández
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/47367a7eaa474af2bf15ce6713e899c7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:47367a7eaa474af2bf15ce6713e899c7
record_format	dspace
spelling	oai:doaj.org-article:47367a7eaa474af2bf15ce6713e899c72021-11-04T06:08:07ZMolecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.1932-620310.1371/journal.pone.0024939https://doaj.org/article/47367a7eaa474af2bf15ce6713e899c72011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21957467/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin's lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports have located this loss in the 7q32 region. In order to better characterize the genomic imbalances in SMZL, molecular studies were carried out in 73 patients with SMZL. To gain insight into the mapping at 7q a tiling array was also used. The results confirmed the loss of 7q as the most frequent change. In addition, several abnormalities, including 4q22.1, 1q21.3-q22, 6q25.3, 20q13.33, 3q28, 2q23.3-q24.1 and 17p13, were also present. A loss of 7q22.1 at 99925039-101348479 bp was observed in half of the cases. The region of 7q22.1 has not previously been characterised in SMZL. Our results confirmed the presence of a new region of loss on chromosome 7 in these NHL.Cristina RobledoJuan L GarcíaRocío BenitoTeresa FloresManuela MollejoJosé Ángel Martínez-ClimentEva GarcíaNorma C GutiérrezMiguel A PirisJesús M HernándezPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 9, p e24939 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Cristina Robledo Juan L García Rocío Benito Teresa Flores Manuela Mollejo José Ángel Martínez-Climent Eva García Norma C Gutiérrez Miguel A Piris Jesús M Hernández Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.
description	Splenic marginal zone lymphomas (SMZL) are an uncommon type of B-cell non-Hodgkin's lymphoma (NHL-B) in which no specific chromosomal translocations have been described. In contrast, the most frequent cytogenetic abnormality is the loss of the long arm of chromosome 7 (7q). Previous reports have located this loss in the 7q32 region. In order to better characterize the genomic imbalances in SMZL, molecular studies were carried out in 73 patients with SMZL. To gain insight into the mapping at 7q a tiling array was also used. The results confirmed the loss of 7q as the most frequent change. In addition, several abnormalities, including 4q22.1, 1q21.3-q22, 6q25.3, 20q13.33, 3q28, 2q23.3-q24.1 and 17p13, were also present. A loss of 7q22.1 at 99925039-101348479 bp was observed in half of the cases. The region of 7q22.1 has not previously been characterised in SMZL. Our results confirmed the presence of a new region of loss on chromosome 7 in these NHL.
format	article
author	Cristina Robledo Juan L García Rocío Benito Teresa Flores Manuela Mollejo José Ángel Martínez-Climent Eva García Norma C Gutiérrez Miguel A Piris Jesús M Hernández
author_facet	Cristina Robledo Juan L García Rocío Benito Teresa Flores Manuela Mollejo José Ángel Martínez-Climent Eva García Norma C Gutiérrez Miguel A Piris Jesús M Hernández
author_sort	Cristina Robledo
title	Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.
title_short	Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.
title_full	Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.
title_fullStr	Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.
title_full_unstemmed	Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.
title_sort	molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/47367a7eaa474af2bf15ce6713e899c7
work_keys_str_mv	AT cristinarobledo molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT juanlgarcia molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT rociobenito molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT teresaflores molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT manuelamollejo molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT joseangelmartinezcliment molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT evagarcia molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT normacgutierrez molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT miguelapiris molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas AT jesusmhernandez molecularcharacterizationoftheregion7q221insplenicmarginalzonelymphomas
_version_	1718445146899480576

Molecular characterization of the region 7q22.1 in splenic marginal zone lymphomas.

Ejemplares similares