Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes

Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes.

Guardado en:
Detalles Bibliográficos
Autores principales: Alexander P. S. Darlington, Juhyun Kim, José I. Jiménez, Declan G. Bates
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Q
Acceso en línea:https://doaj.org/article/47372b41d6ad4afa9243f6baf5c79a1b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes.