Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes

Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes.

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Autores principales:	Alexander P. S. Darlington, Juhyun Kim, José I. Jiménez, Declan G. Bates
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/47372b41d6ad4afa9243f6baf5c79a1b
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spelling	oai:doaj.org-article:47372b41d6ad4afa9243f6baf5c79a1b2021-12-02T15:33:46ZDynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes10.1038/s41467-018-02898-62041-1723https://doaj.org/article/47372b41d6ad4afa9243f6baf5c79a1b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02898-6https://doaj.org/toc/2041-1723Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes.Alexander P. S. DarlingtonJuhyun KimJosé I. JiménezDeclan G. BatesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander P. S. Darlington Juhyun Kim José I. Jiménez Declan G. Bates Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
description	Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes.
format	article
author	Alexander P. S. Darlington Juhyun Kim José I. Jiménez Declan G. Bates
author_facet	Alexander P. S. Darlington Juhyun Kim José I. Jiménez Declan G. Bates
author_sort	Alexander P. S. Darlington
title	Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
title_short	Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
title_full	Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
title_fullStr	Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
title_full_unstemmed	Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
title_sort	dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/47372b41d6ad4afa9243f6baf5c79a1b
work_keys_str_mv	AT alexanderpsdarlington dynamicallocationoforthogonalribosomesfacilitatesuncouplingofcoexpressedgenes AT juhyunkim dynamicallocationoforthogonalribosomesfacilitatesuncouplingofcoexpressedgenes AT joseijimenez dynamicallocationoforthogonalribosomesfacilitatesuncouplingofcoexpressedgenes AT declangbates dynamicallocationoforthogonalribosomesfacilitatesuncouplingofcoexpressedgenes
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Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes

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