Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes
Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes.
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2018
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oai:doaj.org-article:47372b41d6ad4afa9243f6baf5c79a1b2021-12-02T15:33:46ZDynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes10.1038/s41467-018-02898-62041-1723https://doaj.org/article/47372b41d6ad4afa9243f6baf5c79a1b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02898-6https://doaj.org/toc/2041-1723Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes.Alexander P. S. DarlingtonJuhyun KimJosé I. JiménezDeclan G. BatesNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018) |
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Science Q Alexander P. S. Darlington Juhyun Kim José I. Jiménez Declan G. Bates Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes |
description |
Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes. |
format |
article |
author |
Alexander P. S. Darlington Juhyun Kim José I. Jiménez Declan G. Bates |
author_facet |
Alexander P. S. Darlington Juhyun Kim José I. Jiménez Declan G. Bates |
author_sort |
Alexander P. S. Darlington |
title |
Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes |
title_short |
Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes |
title_full |
Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes |
title_fullStr |
Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes |
title_full_unstemmed |
Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes |
title_sort |
dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/47372b41d6ad4afa9243f6baf5c79a1b |
work_keys_str_mv |
AT alexanderpsdarlington dynamicallocationoforthogonalribosomesfacilitatesuncouplingofcoexpressedgenes AT juhyunkim dynamicallocationoforthogonalribosomesfacilitatesuncouplingofcoexpressedgenes AT joseijimenez dynamicallocationoforthogonalribosomesfacilitatesuncouplingofcoexpressedgenes AT declangbates dynamicallocationoforthogonalribosomesfacilitatesuncouplingofcoexpressedgenes |
_version_ |
1718387021229064192 |