Dynamic allocation of orthogonal ribosomes facilitates uncoupling of co-expressed genes

Competition between synthetic genetic circuits and host genes for shared resources can complicate circuit design and lead to failure. Here the authors demonstrate, mathematically and experimentally, the use of orthogonal ribosomes to decouple competing genes.

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Bibliographic Details
Main Authors: Alexander P. S. Darlington, Juhyun Kim, José I. Jiménez, Declan G. Bates
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Q
Online Access:https://doaj.org/article/47372b41d6ad4afa9243f6baf5c79a1b
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