The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV

The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV

Cellular nonsense-mediated mRNA decay (NMD) has been shown to play a role in defense against RNA viruses. Here, Zhao et al. show that NMD restricts the DNA virus Kaposi sarcoma-associated herpesvirus (KSHV) via targeting both cellular and viral transcripts leading to inhibition of KSHV lytic reactiv...

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Autores principales: Yang Zhao, Xiang Ye, Myriam Shehata, William Dunker, Zhihang Xie, John Karijolich
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/47378b33636d47899ccf826a68775637
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spelling oai:doaj.org-article:47378b33636d47899ccf826a687756372021-12-02T16:32:09ZThe RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV10.1038/s41467-020-17151-22041-1723https://doaj.org/article/47378b33636d47899ccf826a687756372020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17151-2https://doaj.org/toc/2041-1723Cellular nonsense-mediated mRNA decay (NMD) has been shown to play a role in defense against RNA viruses. Here, Zhao et al. show that NMD restricts the DNA virus Kaposi sarcoma-associated herpesvirus (KSHV) via targeting both cellular and viral transcripts leading to inhibition of KSHV lytic reactivation.Yang ZhaoXiang YeMyriam ShehataWilliam DunkerZhihang XieJohn KarijolichNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yang Zhao
Xiang Ye
Myriam Shehata
William Dunker
Zhihang Xie
John Karijolich
The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
description Cellular nonsense-mediated mRNA decay (NMD) has been shown to play a role in defense against RNA viruses. Here, Zhao et al. show that NMD restricts the DNA virus Kaposi sarcoma-associated herpesvirus (KSHV) via targeting both cellular and viral transcripts leading to inhibition of KSHV lytic reactivation.
format article
author Yang Zhao
Xiang Ye
Myriam Shehata
William Dunker
Zhihang Xie
John Karijolich
author_facet Yang Zhao
Xiang Ye
Myriam Shehata
William Dunker
Zhihang Xie
John Karijolich
author_sort Yang Zhao
title The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
title_short The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
title_full The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
title_fullStr The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
title_full_unstemmed The RNA quality control pathway nonsense-mediated mRNA decay targets cellular and viral RNAs to restrict KSHV
title_sort rna quality control pathway nonsense-mediated mrna decay targets cellular and viral rnas to restrict kshv
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/47378b33636d47899ccf826a68775637
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