Effect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis

Background: Oral and dental diseases are among the common health conditions which can have different effects on the individuals’ health and quality of life. The objective of this study was to examine the effect of garlic (Allium sativum) extract on saliva Streptococcus mutans (primary outcome) and i...

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Autores principales:	Mostafa Torbati, Parya Emamverdizadeh, Mohammadalili Torbati, Mahsa Maghalian, Mojgan Mirghafourvand
Formato:	article
Lenguaje:	EN
Publicado:	Tabriz University of Medical Sciences 2021
Materias:	allicin garlic streptococcus mutans saliva Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/4739cfa4d03444a29a96307e49779084
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spelling	oai:doaj.org-article:4739cfa4d03444a29a96307e497790842021-11-29T05:49:12ZEffect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis2383-288610.34172/PS.2021.37https://doaj.org/article/4739cfa4d03444a29a96307e497790842021-12-01T00:00:00Zhttps://ps.tbzmed.ac.ir/PDF/ps-27-472.pdfhttps://doaj.org/toc/2383-2886Background: Oral and dental diseases are among the common health conditions which can have different effects on the individuals’ health and quality of life. The objective of this study was to examine the effect of garlic (Allium sativum) extract on saliva Streptococcus mutans (primary outcome) and its side effects (secondary outcome). Methods: In the present systematic review and meta-analysis, English and Persian databases(PubMed, Cochrane Library, Google Scholar, Scopus, SID, and Magiran) were systematically searched until February 25, 2021. The quality of the included studies was examined using Cochranehandbook, and the meta-analysis was carried out using RevMan 5.3. Heterogeneity of the studies was analyzed by index I2. Moreover, the quality of the evidence was assessed through GRADE approach. Results: A total of 93 studies were found on the databases; 89 articles were screened by title and abstract review and were removed as 19 studies were repetitive and 70 studies were unrelated to the subject under study. Ultimately, 4 articles with a sample size of 171 participants were included in this study, and two of the four studies were meta-analyzed. In all four studies, garlic extract was effective in reducing the number of saliva Streptococcus mutans colonies compared to the control group. The results of the meta-analysis showed that using garlic extract mouthwash significantly decreased the average number of saliva Streptococcus mutans colonies (Mean Difference: -3.32; 95%CI: -4.39 to -2.26; P<0.00001). Conclusion: Although this review study indicated the significant effect of garlic extract in reducing saliva Streptococcus mutans, the evidence is not sufficient enough to recommend garlic extract to fight saliva Streptococcus mutans, and more clinical trials with stronger designs and larger sample sizes are needed.Mostafa TorbatiParya EmamverdizadehMohammadalili TorbatiMahsa MaghalianMojgan MirghafourvandTabriz University of Medical Sciencesarticleallicingarlicstreptococcus mutanssalivaPharmacy and materia medicaRS1-441ENPharmaceutical Sciences, Vol 27, Iss 4, Pp 472-480 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	allicin garlic streptococcus mutans saliva Pharmacy and materia medica RS1-441
spellingShingle	allicin garlic streptococcus mutans saliva Pharmacy and materia medica RS1-441 Mostafa Torbati Parya Emamverdizadeh Mohammadalili Torbati Mahsa Maghalian Mojgan Mirghafourvand Effect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis
description	Background: Oral and dental diseases are among the common health conditions which can have different effects on the individuals’ health and quality of life. The objective of this study was to examine the effect of garlic (Allium sativum) extract on saliva Streptococcus mutans (primary outcome) and its side effects (secondary outcome). Methods: In the present systematic review and meta-analysis, English and Persian databases(PubMed, Cochrane Library, Google Scholar, Scopus, SID, and Magiran) were systematically searched until February 25, 2021. The quality of the included studies was examined using Cochranehandbook, and the meta-analysis was carried out using RevMan 5.3. Heterogeneity of the studies was analyzed by index I2. Moreover, the quality of the evidence was assessed through GRADE approach. Results: A total of 93 studies were found on the databases; 89 articles were screened by title and abstract review and were removed as 19 studies were repetitive and 70 studies were unrelated to the subject under study. Ultimately, 4 articles with a sample size of 171 participants were included in this study, and two of the four studies were meta-analyzed. In all four studies, garlic extract was effective in reducing the number of saliva Streptococcus mutans colonies compared to the control group. The results of the meta-analysis showed that using garlic extract mouthwash significantly decreased the average number of saliva Streptococcus mutans colonies (Mean Difference: -3.32; 95%CI: -4.39 to -2.26; P<0.00001). Conclusion: Although this review study indicated the significant effect of garlic extract in reducing saliva Streptococcus mutans, the evidence is not sufficient enough to recommend garlic extract to fight saliva Streptococcus mutans, and more clinical trials with stronger designs and larger sample sizes are needed.
format	article
author	Mostafa Torbati Parya Emamverdizadeh Mohammadalili Torbati Mahsa Maghalian Mojgan Mirghafourvand
author_facet	Mostafa Torbati Parya Emamverdizadeh Mohammadalili Torbati Mahsa Maghalian Mojgan Mirghafourvand
author_sort	Mostafa Torbati
title	Effect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis
title_short	Effect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis
title_full	Effect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis
title_fullStr	Effect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis
title_full_unstemmed	Effect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis
title_sort	effect of garlic (allium sativum) extract on salivary streptococcus mutans: a systematic review and meta-analysis
publisher	Tabriz University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/4739cfa4d03444a29a96307e49779084
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Effect of Garlic (Allium sativum) Extract on Salivary Streptococcus mutans: A Systematic Review and Meta-Analysis

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