Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA

Acquired resistance is a major problem in cancer immunotherapy. Here the authors report a study of two patients with Merkel cell carcinoma under immunotherapy treatment who develop resistance after deep responses for >1 year and identified a novel mechanism of acquired, gene-specific transcriptio...

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Autores principales: K. G. Paulson, V. Voillet, M. S. McAfee, D. S. Hunter, F. D. Wagener, M. Perdicchio, W. J. Valente, S. J. Koelle, C. D. Church, N. Vandeven, H. Thomas, A. G. Colunga, J. G. Iyer, C. Yee, R. Kulikauskas, D. M. Koelle, R. H. Pierce, J. H. Bielas, P. D. Greenberg, S. Bhatia, R. Gottardo, P. Nghiem, A. G. Chapuis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/473d7b036b4c408a879dd4df2f3e7eb3
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spelling oai:doaj.org-article:473d7b036b4c408a879dd4df2f3e7eb32021-12-02T14:40:06ZAcquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA10.1038/s41467-018-06300-32041-1723https://doaj.org/article/473d7b036b4c408a879dd4df2f3e7eb32018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06300-3https://doaj.org/toc/2041-1723Acquired resistance is a major problem in cancer immunotherapy. Here the authors report a study of two patients with Merkel cell carcinoma under immunotherapy treatment who develop resistance after deep responses for >1 year and identified a novel mechanism of acquired, gene-specific transcriptional suppression of HLAs.K. G. PaulsonV. VoilletM. S. McAfeeD. S. HunterF. D. WagenerM. PerdicchioW. J. ValenteS. J. KoelleC. D. ChurchN. VandevenH. ThomasA. G. ColungaJ. G. IyerC. YeeR. KulikauskasD. M. KoelleR. H. PierceJ. H. BielasP. D. GreenbergS. BhatiaR. GottardoP. NghiemA. G. ChapuisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
K. G. Paulson
V. Voillet
M. S. McAfee
D. S. Hunter
F. D. Wagener
M. Perdicchio
W. J. Valente
S. J. Koelle
C. D. Church
N. Vandeven
H. Thomas
A. G. Colunga
J. G. Iyer
C. Yee
R. Kulikauskas
D. M. Koelle
R. H. Pierce
J. H. Bielas
P. D. Greenberg
S. Bhatia
R. Gottardo
P. Nghiem
A. G. Chapuis
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
description Acquired resistance is a major problem in cancer immunotherapy. Here the authors report a study of two patients with Merkel cell carcinoma under immunotherapy treatment who develop resistance after deep responses for >1 year and identified a novel mechanism of acquired, gene-specific transcriptional suppression of HLAs.
format article
author K. G. Paulson
V. Voillet
M. S. McAfee
D. S. Hunter
F. D. Wagener
M. Perdicchio
W. J. Valente
S. J. Koelle
C. D. Church
N. Vandeven
H. Thomas
A. G. Colunga
J. G. Iyer
C. Yee
R. Kulikauskas
D. M. Koelle
R. H. Pierce
J. H. Bielas
P. D. Greenberg
S. Bhatia
R. Gottardo
P. Nghiem
A. G. Chapuis
author_facet K. G. Paulson
V. Voillet
M. S. McAfee
D. S. Hunter
F. D. Wagener
M. Perdicchio
W. J. Valente
S. J. Koelle
C. D. Church
N. Vandeven
H. Thomas
A. G. Colunga
J. G. Iyer
C. Yee
R. Kulikauskas
D. M. Koelle
R. H. Pierce
J. H. Bielas
P. D. Greenberg
S. Bhatia
R. Gottardo
P. Nghiem
A. G. Chapuis
author_sort K. G. Paulson
title Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
title_short Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
title_full Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
title_fullStr Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
title_full_unstemmed Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA
title_sort acquired cancer resistance to combination immunotherapy from transcriptional loss of class i hla
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/473d7b036b4c408a879dd4df2f3e7eb3
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