Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center

Immunoassays are widely used as screening tests for HIV and syphilis in clinical, public health, and research settings. For syphilis, immunoassays are used in 'reverse syphilis algorithms' that start with treponemal tests such as syphilis IgG or syphilis total antibodies for the initial sc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Saurav Chopra, Matthew D. Krasowski
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	False positive reaction HIV-1 immunoassay syphilis Treponema pallidum viral load Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
Acceso en línea:	https://doaj.org/article/473e968512d34f76b46759098dba7cfd
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:473e968512d34f76b46759098dba7cfd
record_format	dspace
spelling	oai:doaj.org-article:473e968512d34f76b46759098dba7cfd2021-11-12T04:38:03ZData on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center2352-340910.1016/j.dib.2021.107549https://doaj.org/article/473e968512d34f76b46759098dba7cfd2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2352340921008258https://doaj.org/toc/2352-3409Immunoassays are widely used as screening tests for HIV and syphilis in clinical, public health, and research settings. For syphilis, immunoassays are used in 'reverse syphilis algorithms' that start with treponemal tests such as syphilis IgG or syphilis total antibodies for the initial screen. Many screening immunoassays for HIV and syphilis use signal-to-cutoff (S/CO) values for determining positivity, with a cutoff value such as 1.0 differentiating positive from negative. Published literature indicates that the S/CO value often correlates with the likelihood of subsequent confirmation of HIV and syphilis infections, with low S/CO values barely exceeding the cutoff more likely to represent false positive screens. The data in this article present results from the Roche Diagnostics Elecsys HIV combi PT Assay and the Elecsys Syphilis Assay. The data include 19,368 syphilis total antibody screening results on 15,764 unique patients and 28,952 HIV screening results on 24,556 unique patients, S/CO values, clinical area where testing was ordered, sex, and age. For samples with positive syphilis total antibody screens, the data also include results of RPR (the immediate next step in the reverse algorithm), Treponema pallidum particle agglutination (TP-PA; for those samples in which RPR was non-reactive in the testing cascade), and clinical information and other testing related to diagnosis of syphilis. For positive HIV screens, the data also include HIV antibody differentiation results, HIV-1 PCR or HIV-2 results results (if performed), and clinical information related to diagnosis of HIV. The distributions of S/CO values relative to confirmation status were analyzed.Saurav ChopraMatthew D. KrasowskiElsevierarticleFalse positive reactionHIV-1immunoassaysyphilisTreponema pallidumviral loadComputer applications to medicine. Medical informaticsR858-859.7Science (General)Q1-390ENData in Brief, Vol 39, Iss , Pp 107549- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	False positive reaction HIV-1 immunoassay syphilis Treponema pallidum viral load Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390
spellingShingle	False positive reaction HIV-1 immunoassay syphilis Treponema pallidum viral load Computer applications to medicine. Medical informatics R858-859.7 Science (General) Q1-390 Saurav Chopra Matthew D. Krasowski Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center
description	Immunoassays are widely used as screening tests for HIV and syphilis in clinical, public health, and research settings. For syphilis, immunoassays are used in 'reverse syphilis algorithms' that start with treponemal tests such as syphilis IgG or syphilis total antibodies for the initial screen. Many screening immunoassays for HIV and syphilis use signal-to-cutoff (S/CO) values for determining positivity, with a cutoff value such as 1.0 differentiating positive from negative. Published literature indicates that the S/CO value often correlates with the likelihood of subsequent confirmation of HIV and syphilis infections, with low S/CO values barely exceeding the cutoff more likely to represent false positive screens. The data in this article present results from the Roche Diagnostics Elecsys HIV combi PT Assay and the Elecsys Syphilis Assay. The data include 19,368 syphilis total antibody screening results on 15,764 unique patients and 28,952 HIV screening results on 24,556 unique patients, S/CO values, clinical area where testing was ordered, sex, and age. For samples with positive syphilis total antibody screens, the data also include results of RPR (the immediate next step in the reverse algorithm), Treponema pallidum particle agglutination (TP-PA; for those samples in which RPR was non-reactive in the testing cascade), and clinical information and other testing related to diagnosis of syphilis. For positive HIV screens, the data also include HIV antibody differentiation results, HIV-1 PCR or HIV-2 results results (if performed), and clinical information related to diagnosis of HIV. The distributions of S/CO values relative to confirmation status were analyzed.
format	article
author	Saurav Chopra Matthew D. Krasowski
author_facet	Saurav Chopra Matthew D. Krasowski
author_sort	Saurav Chopra
title	Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center
title_short	Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center
title_full	Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center
title_fullStr	Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center
title_full_unstemmed	Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center
title_sort	data on the relationships of signal-to-cutoff ratios of elecsys hiv antigen/antibody and elecsys syphilis assays to subsequent confirmatory testing at an academic medical center
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/473e968512d34f76b46759098dba7cfd
work_keys_str_mv	AT sauravchopra dataontherelationshipsofsignaltocutoffratiosofelecsyshivantigenantibodyandelecsyssyphilisassaystosubsequentconfirmatorytestingatanacademicmedicalcenter AT matthewdkrasowski dataontherelationshipsofsignaltocutoffratiosofelecsyshivantigenantibodyandelecsyssyphilisassaystosubsequentconfirmatorytestingatanacademicmedicalcenter
_version_	1718431227373944832

Data on the Relationships of Signal-To-Cutoff Ratios of Elecsys HIV Antigen/Antibody and Elecsys Syphilis Assays to Subsequent Confirmatory Testing at an Academic Medical Center

Ejemplares similares