Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines

Abstract Dendritic cell (DC)-based cancer vaccines have so far achieved good therapeutic effects in animal experiments and early clinical trials for certain malignant tumors. However, the overall objective response rate in clinical trials rarely exceeds 15%. The poor efficiency of DC migration to ly...

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Autores principales:	Rui Zhang, Lin Tang, Qing Li, Yaomei Tian, Binyan Zhao, Bailing Zhou, Li Yang
Formato:	article
Lenguaje:	EN
Publicado:	Springer 2021
Materias:	DC vaccine DC migration DP7-C Pantothenic acid miR-142a-3p Medicine R
Acceso en línea:	https://doaj.org/article/473fc7fe717c4bc6b718b431e9beb70b
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spelling	oai:doaj.org-article:473fc7fe717c4bc6b718b431e9beb70b2021-12-05T12:04:48ZCholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines10.1186/s43556-021-00058-92662-8651https://doaj.org/article/473fc7fe717c4bc6b718b431e9beb70b2021-12-01T00:00:00Zhttps://doi.org/10.1186/s43556-021-00058-9https://doaj.org/toc/2662-8651Abstract Dendritic cell (DC)-based cancer vaccines have so far achieved good therapeutic effects in animal experiments and early clinical trials for certain malignant tumors. However, the overall objective response rate in clinical trials rarely exceeds 15%. The poor efficiency of DC migration to lymph nodes (LNs) (< 5%) is one of the main factors limiting the effectiveness of DC vaccines. Therefore, increasing the efficiency of DC migration is expected to further enhance the efficacy of DC vaccines. Here, we used DP7-C (cholesterol modified VQWRIRVAVIRK), which can promote DC migration, as a medium. Through multiomics sequencing and biological experiments, we found that it is the metabolite pantothenic acid (PA) that improves the migration and effectiveness of DC vaccines. We clarified that both DP7-C and PA regulate DC migration by regulating the chemokine receptor CXCR2 and inhibiting miR-142a-3p to affect the NF-κB signaling pathway. This study will lay the foundation for the subsequent use of DP7-C as a universal substance to promote DC migration, further enhance the antitumor effect of DC vaccines, and solve the bottleneck problem of the low migration efficiency and unsatisfactory clinical response rate of DC vaccines.Rui ZhangLin TangQing LiYaomei TianBinyan ZhaoBailing ZhouLi YangSpringerarticleDC vaccineDC migrationDP7-CPantothenic acidmiR-142a-3pMedicineRENMolecular Biomedicine, Vol 2, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DC vaccine DC migration DP7-C Pantothenic acid miR-142a-3p Medicine R
spellingShingle	DC vaccine DC migration DP7-C Pantothenic acid miR-142a-3p Medicine R Rui Zhang Lin Tang Qing Li Yaomei Tian Binyan Zhao Bailing Zhou Li Yang Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines
description	Abstract Dendritic cell (DC)-based cancer vaccines have so far achieved good therapeutic effects in animal experiments and early clinical trials for certain malignant tumors. However, the overall objective response rate in clinical trials rarely exceeds 15%. The poor efficiency of DC migration to lymph nodes (LNs) (< 5%) is one of the main factors limiting the effectiveness of DC vaccines. Therefore, increasing the efficiency of DC migration is expected to further enhance the efficacy of DC vaccines. Here, we used DP7-C (cholesterol modified VQWRIRVAVIRK), which can promote DC migration, as a medium. Through multiomics sequencing and biological experiments, we found that it is the metabolite pantothenic acid (PA) that improves the migration and effectiveness of DC vaccines. We clarified that both DP7-C and PA regulate DC migration by regulating the chemokine receptor CXCR2 and inhibiting miR-142a-3p to affect the NF-κB signaling pathway. This study will lay the foundation for the subsequent use of DP7-C as a universal substance to promote DC migration, further enhance the antitumor effect of DC vaccines, and solve the bottleneck problem of the low migration efficiency and unsatisfactory clinical response rate of DC vaccines.
format	article
author	Rui Zhang Lin Tang Qing Li Yaomei Tian Binyan Zhao Bailing Zhou Li Yang
author_facet	Rui Zhang Lin Tang Qing Li Yaomei Tian Binyan Zhao Bailing Zhou Li Yang
author_sort	Rui Zhang
title	Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines
title_short	Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines
title_full	Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines
title_fullStr	Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines
title_full_unstemmed	Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines
title_sort	cholesterol modified dp7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines
publisher	Springer
publishDate	2021
url	https://doaj.org/article/473fc7fe717c4bc6b718b431e9beb70b
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Cholesterol modified DP7 and pantothenic acid induce dendritic cell homing to enhance the efficacy of dendritic cell vaccines

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