Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?

The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased per...

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Autores principales:	Michiel van der Flier, Dyana B Sharma, Silvia Estevão, Marieke Emonts, Denise Rook, Jan A Hazelzet, Johannes B van Goudoever, Nico G Hartwig
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4740e15bbebd4577a02e7a5bcf41fa41
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spelling	oai:doaj.org-article:4740e15bbebd4577a02e7a5bcf41fa412021-11-18T09:03:42ZIncreased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?1932-620310.1371/journal.pone.0068294https://doaj.org/article/4740e15bbebd4577a02e7a5bcf41fa412013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23894299/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression.Michiel van der FlierDyana B SharmaSilvia EstevãoMarieke EmontsDenise RookJan A HazelzetJohannes B van GoudoeverNico G HartwigPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 7, p e68294 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michiel van der Flier Dyana B Sharma Silvia Estevão Marieke Emonts Denise Rook Jan A Hazelzet Johannes B van Goudoever Nico G Hartwig Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
description	The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated with increased serum soluble CEACAM1. In conclusion our data demonstrate increased surface expression of the co-inhibitory immune receptor CEACAM1 in late-onset neonatal sepsis in VLBW-infants, and increased circulating soluble CEACAM1 in children with meningococcal sepsis. Increased T-cell CEACAM1 expression and increased circulating soluble CEACAM1 may contribute to sepsis-associated immune suppression.
format	article
author	Michiel van der Flier Dyana B Sharma Silvia Estevão Marieke Emonts Denise Rook Jan A Hazelzet Johannes B van Goudoever Nico G Hartwig
author_facet	Michiel van der Flier Dyana B Sharma Silvia Estevão Marieke Emonts Denise Rook Jan A Hazelzet Johannes B van Goudoever Nico G Hartwig
author_sort	Michiel van der Flier
title	Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
title_short	Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
title_full	Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
title_fullStr	Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
title_full_unstemmed	Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
title_sort	increased cd4(+) t cell co-inhibitory immune receptor ceacam1 in neonatal sepsis and soluble-ceacam1 in meningococcal sepsis: a role in sepsis-associated immune suppression?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/4740e15bbebd4577a02e7a5bcf41fa41
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Increased CD4(+) T cell co-inhibitory immune receptor CEACAM1 in neonatal sepsis and soluble-CEACAM1 in meningococcal sepsis: a role in sepsis-associated immune suppression?

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