Distributed representation of pelvic floor muscles in human motor cortex

Abstract Human motor cortex can activate pelvic floor muscles (PFM), but the motor cortical representation of the PFM is not well characterized. PFM representation is thought to be focused in the supplementary motor area (SMA). Here we examine the degree to which PFM representation is distributed be...

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Autores principales:	Moheb S. Yani, Joyce H. Wondolowski, Sandrah P. Eckel, Kornelia Kulig, Beth E. Fisher, James E. Gordon, Jason J. Kutch
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/4745b8f916ea4c88a98b4972b926d9f2
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spelling	oai:doaj.org-article:4745b8f916ea4c88a98b4972b926d9f22021-12-02T15:08:54ZDistributed representation of pelvic floor muscles in human motor cortex10.1038/s41598-018-25705-02045-2322https://doaj.org/article/4745b8f916ea4c88a98b4972b926d9f22018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25705-0https://doaj.org/toc/2045-2322Abstract Human motor cortex can activate pelvic floor muscles (PFM), but the motor cortical representation of the PFM is not well characterized. PFM representation is thought to be focused in the supplementary motor area (SMA). Here we examine the degree to which PFM representation is distributed between SMA and the primary motor cortex (M1), and how this representation is utilized to activate the PFM in different coordination patterns. We show that two types of coordination patterns involving PFM can be voluntarily accessed: one activates PFM independently of synergists and a second activates PFM prior to and in proportion with synergists (in this study, the gluteus maximus muscle – GMM). Functional magnetic resonance imaging (fMRI) showed that both coordination patterns involve overlapping activation in SMA and M1, suggesting the presence of intermingled but independent neural populations that access the different patterns. Transcranial magnetic stimulation (TMS) confirmed SMA and M1 representation for the PFM. TMS also showed that, equally for SMA and M1, PFM can be activated during rest but GMM can only be activated after voluntary drive to GMM, suggesting that these populations are distinguished by activation threshold. We conclude that PFM representation is broadly distributed in SMA and M1 in humans.Moheb S. YaniJoyce H. WondolowskiSandrah P. EckelKornelia KuligBeth E. FisherJames E. GordonJason J. KutchNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Moheb S. Yani Joyce H. Wondolowski Sandrah P. Eckel Kornelia Kulig Beth E. Fisher James E. Gordon Jason J. Kutch Distributed representation of pelvic floor muscles in human motor cortex
description	Abstract Human motor cortex can activate pelvic floor muscles (PFM), but the motor cortical representation of the PFM is not well characterized. PFM representation is thought to be focused in the supplementary motor area (SMA). Here we examine the degree to which PFM representation is distributed between SMA and the primary motor cortex (M1), and how this representation is utilized to activate the PFM in different coordination patterns. We show that two types of coordination patterns involving PFM can be voluntarily accessed: one activates PFM independently of synergists and a second activates PFM prior to and in proportion with synergists (in this study, the gluteus maximus muscle – GMM). Functional magnetic resonance imaging (fMRI) showed that both coordination patterns involve overlapping activation in SMA and M1, suggesting the presence of intermingled but independent neural populations that access the different patterns. Transcranial magnetic stimulation (TMS) confirmed SMA and M1 representation for the PFM. TMS also showed that, equally for SMA and M1, PFM can be activated during rest but GMM can only be activated after voluntary drive to GMM, suggesting that these populations are distinguished by activation threshold. We conclude that PFM representation is broadly distributed in SMA and M1 in humans.
format	article
author	Moheb S. Yani Joyce H. Wondolowski Sandrah P. Eckel Kornelia Kulig Beth E. Fisher James E. Gordon Jason J. Kutch
author_facet	Moheb S. Yani Joyce H. Wondolowski Sandrah P. Eckel Kornelia Kulig Beth E. Fisher James E. Gordon Jason J. Kutch
author_sort	Moheb S. Yani
title	Distributed representation of pelvic floor muscles in human motor cortex
title_short	Distributed representation of pelvic floor muscles in human motor cortex
title_full	Distributed representation of pelvic floor muscles in human motor cortex
title_fullStr	Distributed representation of pelvic floor muscles in human motor cortex
title_full_unstemmed	Distributed representation of pelvic floor muscles in human motor cortex
title_sort	distributed representation of pelvic floor muscles in human motor cortex
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/4745b8f916ea4c88a98b4972b926d9f2
work_keys_str_mv	AT mohebsyani distributedrepresentationofpelvicfloormusclesinhumanmotorcortex AT joycehwondolowski distributedrepresentationofpelvicfloormusclesinhumanmotorcortex AT sandrahpeckel distributedrepresentationofpelvicfloormusclesinhumanmotorcortex AT korneliakulig distributedrepresentationofpelvicfloormusclesinhumanmotorcortex AT bethefisher distributedrepresentationofpelvicfloormusclesinhumanmotorcortex AT jamesegordon distributedrepresentationofpelvicfloormusclesinhumanmotorcortex AT jasonjkutch distributedrepresentationofpelvicfloormusclesinhumanmotorcortex
_version_	1718387995035303936

Distributed representation of pelvic floor muscles in human motor cortex

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